{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:47:32Z","timestamp":1762508852371,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to investigate the relationship between immediate incomplete stent apposition (ISA) detected by intravascular ultrasound (IVUS) and midterm stent failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Stent failure is one of serious clinical events related to percutaneous coronary intervention (PCI). The previous studies using optical coherence tomography showed that ISA could be associated with stent thrombosis. However, the association between immediate ISA detected by IVUS and stent failure has not been fully investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 396 lesions that underwent elective PCI, and divided those into the appropriate stent apposition (ASA) group (<jats:italic>n<\/jats:italic>\u2009=\u2009290) and the ISA group (<jats:italic>n<\/jats:italic>\u2009=\u2009106). The primary endpoint was stent failure, which was defined as a composite of ischemia\u2010driven target lesion revascularization and stent thrombosis. We compared clinical and lesion characteristics between the two groups, and performed a multivariate COX hazard analysis to investigate the association between immediate ISA and stent failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up duration was 1296 days. The Kaplan\u2212Meier curves revealed the higher incidence of stent failure in the ISA group than in the ASA group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The multivariate stepwise COX hazard analysis showed that immediate ISA (hazard ratio 4.97, 95% confidence interval 1.31\u221218.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) was significantly associated with stent failure. When we set the cut\u2010off value of the immediate ISA distance as 0.25\u2009mm, the distance\u2009\u2265\u20090.25\u2009mm had 68.8% sensitivity and 85.0% specificity to predict stent failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immediate ISA detected by IVUS was associated with midterm stent failure. We should pay attention to reduce immediate ISA for improving the midterm outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30424","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T10:48:47Z","timestamp":1666867727000},"page":"1000-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of intravascular ultrasound\u2010incomplete stent apposition on stent failure"],"prefix":"10.1002","volume":"100","author":[{"given":"Yusuke","family":"Watanabe","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center Jichi Medical University  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-0394","authenticated-orcid":false,"given":"Kenichi","family":"Sakakura","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical 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