{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:10:23Z","timestamp":1773425423188,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The long\u2010term data on the use of drug\u2010coated balloons (DCBs) for femoropopliteal atherosclerotic lesions in the real\u2010world setting are limited, even more so for racially and geographically distinct populations. The present analysis reports the 5\u2010year safety and effectiveness outcomes of a DCB in the Asian subset of the prospective, real\u2010world IN.PACT\u00a0Global Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The IN.PACT\u00a0Global Study was a prospective, multicenter, international, single\u2010arm study designed to assess the long\u2010term safety and effectiveness of the IN.PACT\u00a0Admiral DCB in real\u2010world participants with femoropopliteal artery disease. The present analysis included 114 Asian participants (138 lesions) treated in South Korea and Singapore. Assessments through 5 years included freedom from clinically driven target lesion revascularization, the safety endpoint (a composite of freedom from device\u2010 and procedure\u2010related mortality through 30 days; and freedom from major target limb amputation and clinically driven target vessel revascularization within 60 months after the index procedure) and major adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this prespecified Asian subset, there was a high incidence of diabetes mellitus (54.4%), hypertension (78.1%), coronary artery disease (43.9%), and concomitant below\u2010the\u2010knee vascular disease of target leg (39.5%). Mean lesion length was 17.4\u2009\u00b1\u200912.4\u2009cm; 26.8% were in\u2010stent restenosis, and more than half of the lesions were totally occluded (51.4%) and calcified (54.3%). The 5\u2010year Kaplan\u2013Meier estimate of freedom from clinically driven target lesion revascularization was 77.1% (95% confidence interval: 67.0%\u201384.5%). The safety composite endpoint was 76.0%; the cumulative incidence of all\u2010cause mortality was 19.9%, and no major target limb amputations were reported through 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This subset analysis of Asian participants from the IN.PACT\u00a0Global Study demonstrated consistent results with the previously reported data of the IN.PACT\u00a0Admiral DCB. The data confirm the durable clinical effectiveness and safety profile of the DCB through 5 years for femoropopliteal atherosclerotic disease in this real\u2010world population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30441","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T06:33:11Z","timestamp":1668666791000},"page":"1273-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term outcomes after paclitaxel\u2010coated balloon angioplasty of femoropopliteal arteries in Asian patients of the IN.PACT Global Study"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7748-5788","authenticated-orcid":false,"given":"Young\u2010Guk","family":"Ko","sequence":"first","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-9760","authenticated-orcid":false,"given":"Donghoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-3508","authenticated-orcid":false,"given":"Seung\u2010Woon","family":"Rha","sequence":"additional","affiliation":[{"name":"Division of cardiology Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Hwan","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Radiology Ajou University Hospital Suwon Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Soo","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-5952","authenticated-orcid":false,"given":"Seung\u2010Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah S.","family":"Menk","sequence":"additional","affiliation":[{"name":"Medtronic Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kum","sequence":"additional","affiliation":[{"name":"Department of Surgery Changi General Hospital Singapore 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