{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:46:32Z","timestamp":1788205592967,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether the drug\u2010coated balloons (DCBs)\u2010alone strategy was superior to plain old balloon angioplasty (POBA) in treating SVD remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to evaluate the efficacy and safety of DCBs for the treatment of coronary <jats:italic>d<\/jats:italic>e novo small vessel disease (SVD) and provide further evidence for extending the clinical indications of DCBs. (ChiCTR1800014966).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible patients were randomized at a 2:1 ratio to receive DCB treatment or POBA in this prospective, multicenter clinical trial. The reference vessel diameter of lesions was visually assessed to be 2.0 to 2.75\u2009mm. The primary endpoint of the study was angiographic in\u2010segment late luminal loss (LLL) at the 9\u2010month follow\u2010up to demonstrate the superiority of DCB treatment to POBA in SVD. The composite clinical endpoints included clinically driven target lesion revascularization (CD\u2010TLR), target lesion failure (TLF), major adverse cardiac events (MACEs), and thrombosis at the 12\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 270 patients were enrolled (181 for DCB, 89 for POBA) at 18 centers in China. The primary endpoint of 9\u2010month in\u2010segment LLL in the intention\u2010to\u2010treat population was 0.10\u2009\u00b1\u20090.33\u2009mm with DCB and 0.25\u2009\u00b1\u20090.38\u2009mm with POBA (<jats:italic>p<\/jats:italic>\u2009=\u20090.0027). This difference indicated significant superiority of DCB treatment (95% CI: \u22120.22, \u22120.04, <jats:italic>p<\/jats:italic><jats:sub>superiority<\/jats:sub>\u2009=\u20090.0068). The rates of the clinical endpoints\u2014CD\u2010TLR, TLF, and MACEs\u2014were comparable between groups. No thrombosis events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DCB treatment of de novo SVD was superior to POBA with lower 9\u2010month in\u2010segment LLL. The rates of clinical events were comparable between the two devices.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30472","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T21:09:01Z","timestamp":1670533741000},"page":"33-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Drug\u2010coated balloon for the treatment of small vessel disease: 9 months of angiographic results and 12 months of clinical outcomes of the PEPCAD China SVD study"],"prefix":"10.1002","volume":"101","author":[{"given":"Juying","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine  Shanghai 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