{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:26:45Z","timestamp":1790098005979,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>New\u2010onset left bundle branch block (LBBB) can develop after transcatheter aortic valve replacement (TAVR) resulting in worse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Describe clinical and echocardiographic outcomes with new\u2010onset LBBB after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included consecutive patients who underwent transfemoral\u2010TAVR with SAPIEN\u20103 (S3) valve between April 2015 and December 2018. Exclusion criteria included pre\u2010existing LBBB, right BBB, left anterior hemiblock, left posterior hemiblock, wide QRS\u2009\u2265\u2009120ms, prior permanent pacemaker (PPM), and nontransfemoral access.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 612 patients, 11.4% developed new\u2010onset LBBB upon discharge. The length of stay was longer with new\u2010onset LBBB compared with no LBBB [3 (2\u20135) days versus 2 (1\u20133) days; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]. New\u2010onset LBBB was associated with higher rates of 30\u2010day PPM requirement (18.6% vs. 5.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 1\u2010year heart failure hospitalizations (10.7% vs. 4.4%; <jats:italic>p<\/jats:italic>\u2009=\u20090.033). There was no difference in 3\u2010year mortality between both groups (30.9% vs. 30.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.829). Further, new\u2010onset LBBB was associated with lower left ventricular ejection fraction (LVEF) at both 30 days (55.9\u2009\u00b1\u200911.4% vs. 59.3\u2009\u00b1\u20099%; <jats:italic>p<\/jats:italic>\u2009=\u20090.026) and 1 year (55\u2009\u00b1\u200912% vs. 60.1\u2009\u00b1\u20098.9%; <jats:italic>p<\/jats:italic>\u2009=\u20090.002). These changes were still present when we stratified patients according to baseline LVEF (\u226550% or &lt;50%). New\u2010onset LBBBs were associated with a higher 1\u2010year LV end\u2010diastolic volume index (51.4\u2009\u00b1\u200918.6 vs. 46.4\u2009\u00b1\u200915.1\u2009ml\/m<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.036), and LV end\u2010systolic volume index (23.2\u2009\u00b1\u200914.1 vs. 18.9\u2009\u00b1\u20099.7\u2009ml\/m<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.009). Compared with resolved new\u2010onset LBBB, persistent new\u2010onset LBBB was associated with worse LVEF and higher PPM at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>New\u2010onset LBBB after S3 TAVR was associated with higher PPM requirement, worse LVEF, higher LV volumes, and increased heart failure hospitalizations, with no difference in mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30488","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T18:20:56Z","timestamp":1668536456000},"page":"187-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and echocardiographic outcomes with new\u2010onset left bundle branch block after SAPIEN\u20103 transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"101","author":[{"given":"Yasser M.","family":"Sammour","sequence":"first","affiliation":[{"name":"Department of 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