{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:58:11Z","timestamp":1782813491374,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). OAC treatment has been proven feasible in mild\u2010to\u2010moderate chronic kidney disease (CKD). In contrast, the optimal antithrombotic management of AF patients with end\u2010stage renal disease (ESRD) is unknown and LAAC has not been proven in these patients in prospective randomized clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study is to evaluate safety and efficacy of LAAC in patients with ESRD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing LAAC were collected in a German multicenter real\u2010world observational registry. A composite endpoint consisting of the occurrence of ischemic stroke\/transient ischemic attack, systemic embolism, and\/or major clinical bleeding was assessed. Patients with ESRD were compared with propensity score\u2010matched patients without severe CKD. ESRD was defined as a glomerular filtration rate\u2009&lt;\u200915\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> or chronic hemodialysis treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 604 patients were analyzed, including 57 with ESRD and 57 propensity\u2010matched patients. Overall, 596 endocardial and 8 epicardial LAAC procedures were performed. Frequency of major complications was 7.0% (42\/604 patients) in the overall cohort, 8.8% (5\/57 patients) in patients with ESRD, and 10.5% (6\/57 patients) in matched controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.75). The estimated event\u2010free survival of the combined endpoint after 500 days was 90.7\u2009\u00b1\u20094.5% in patients with ESRD and 90.2\u2009\u00b1\u20095.5% in matched controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LAAC had comparable procedural safety and clinical efficacy in patients with ESRD and patients without severe CKD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30559","type":"journal-article","created":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T22:44:46Z","timestamp":1674427486000},"page":"610-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Left atrial appendage closure in end\u2010stage renal disease and hemodialysis: Data from a German multicenter registry"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-7326","authenticated-orcid":false,"given":"Thomas","family":"Fink","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-9693","authenticated-orcid":false,"given":"Christina","family":"Paitazoglou","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Cardiologicum Hamburg  Hamburg Germany"},{"name":"Department of Cardiology Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Cardiologicum Hamburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-3257","authenticated-orcid":false,"given":"Makoto","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Keelani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Clinic for Electrophysiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Cardiology University Hospital Schleswig\u2010Holstein  Kiel Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Eitel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian\u2010Hendrik","family":"Heeger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Skurk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 University Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-3203","authenticated-orcid":false,"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 University Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-8772","authenticated-orcid":false,"given":"Georg","family":"Fuernau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Christian","family":"Reil","sequence":"additional","affiliation":[{"name":"Department of Cardiology Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Clinic for General and Interventional Cardiology\/Angiology, Herz\u2010 und Diabeteszentrum NRW Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Schleswig\u2010Holstein  Kiel Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"},{"name":"Department of Cardiology, Angiology and Pneumology University Hospital Heidelberg  Heidelberg Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Heidelberg\/Mannheim  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"},{"name":"LANS Medicum Hamburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland R.","family":"Tilz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Sandri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine\u2013Division of Electrophysiology University Heart Center L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site  Hamburg\/Kiel\/L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.020982"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.957100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105594"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01810407"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.051"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.05.358"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000441"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1719"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035418"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.10.059"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11650919"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13383"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.021"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.006841"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I1A18"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs416"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12281"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.170"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa169"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-020-01638-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1097-0"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-018-1157-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00774-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035418"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:56:42Z","timestamp":1692730602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,22]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/ccd.30559"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30559","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,22]]},"assertion":[{"value":"2022-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}