{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:04:57Z","timestamp":1788966297231,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ventricular arrhythmia incidence in children and adolescents undergoing transcatheter pulmonary valve replacement (TPVR) within the native right ventricular outflow tract (nRVOT) is unknown. We sought to describe the incidence, severity, and duration of ventricular arrhythmias and identify associated risk factors in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of 78 patients &lt;21 years of age who underwent TPVR within the nRVOT. Patients were excluded for pre\u2010existing ventricular arrhythmia or antiarrhythmic use. Study variables included\u00a0surgical history, valve replacement indication, valve type\/size, and ventricular arrhythmia. Univariable logistic regression models were used to evaluate factors associated with ventricular arrhythmias, followed by subset analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nonsustained ventricular arrhythmia occurred in 26\/78 patients (33.3%). The median age at the procedure was 10.3 years (interquartle range [IQR]: 6.5, 12.8). Compared with other nRVOT types, surgical repair with transannular patch was protective against ventricular arrhythmia incidence: odds ratio (OR): 0.35 (95% confidence interval [CI], 0.13\u20130.95). Patient weight, valve type\/size, number of prestents, and degree of stent extension into the RVOT were not associated with ventricular arrhythmia occurrence. Beta blocker was started in 16\/26 (61.5%) patients with ventricular arrhythmia. One additional patient was lost to follow\u2010up. The median beta blocker duration was 46 days (IQR 42, 102). Beta blocker was discontinued in 10 patients by 8\u2010week follow\u2010up and in the remaining four by 9 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Though common after balloon\u2010expandable TPVR within the nRVOT, ventricular arrhythmias were benign and transient. Antiarrhythmic medications were successfully discontinued in the majority at 6\u2010 to 8\u2010week follow\u2010up, and in all patients by 20 months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30560","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T17:09:36Z","timestamp":1675012176000},"page":"379-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ventricular arrhythmias following balloon\u2010expandable transcatheter pulmonary valve replacement in the native right ventricular outflow tract"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9936-5098","authenticated-orcid":false,"given":"Spencer B.","family":"Barfuss","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Samayoa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Washington and Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Etheridge","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Pilcher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Yukiko","family":"Asaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Epidemiology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-2674","authenticated-orcid":false,"given":"Dana M.","family":"Boucek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Hunt","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-0543","authenticated-orcid":false,"given":"Robert G.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of Utah and Primary Children's Hospital  Salt Lake City Utah 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R Foundation for Statistical Computing.\u00a0https:\/\/www.R-project.org\/."}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T12:10:41Z","timestamp":1692360641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/ccd.30560"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30560","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,29]]},"assertion":[{"value":"2022-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}