{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:33:40Z","timestamp":1788968020945,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postinfarct ventricular septal rupture is a serious complication in delayed or failed reperfusion with a grim prognosis. The optimal timing and treatment option remain debatable in the absence of randomized controlled trials. Percutaneous device closure is a well\u2010reported and less invasive treatment option but recent imaging studies indicate that majority of defects are too large to be adequately covered by the currently Conformite Europeenne and Food and Drug Administration approved occluder devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six patients presented with large and complex postinfarct ventricular septal ruptures, considered unsuitable for the Amplatzer post\u2010infarct ventricular septal defect Occluder, so\u00a0were treated using the prototype Occlutech\u00ae 36\u2009mm PI\u2010VSD occluder, including the first\u2010in\u2010human use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prototype device was successfully deployed in all patients with satisfactory immediate results and shunt reduction. Three patients (50%) in cardiogenic shock did not survive beyond discharge, of which two were complicated by device dislodgement or embolization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Percutaneous closure of large postinfarct ventricular septal ruptures is possible using newer device with a wider coverage. Further device refinement is necessary to improve treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30571","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T06:20:05Z","timestamp":1677392405000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcatheter closure of large postinfarct ventricular septal defect: Initial results of prototype Occlutech\u00ae device including the first\u2010in\u2010human"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-6091","authenticated-orcid":false,"given":"Kuo Ting","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bristol Heart Institute, Bristol Royal Infirmary University Hospitals Bristol and Weston NHS Foundation Trust  Bristol 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