{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:42:09Z","timestamp":1785768129989,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Unprotected left main coronary artery (ULMCA) occlusion is a rare and disastrous condition with scarce data on presentation and outcomes. Herein, we report data on patients presenting with acute coronary syndrome\u00a0due to ULMCA occlusion at four different institutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an international multicentre observational study. Baseline characteristics were retro\u2010 and prospectively collected. Clinical follow\u2010up was prospective. The primary outcome was in\u2010hospital death. Patients surviving the index hospitalization were compared with nonsurvivors to find predictors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population consisted of 55 patients. Eight patients (15%) died in the cath lab, and 23 (42%) died in hospital. Three (6%) deaths were noncardiac and due to major bleeding. Thirty\u2010two (58%) patients survived the index hospitalization and were discharged. These patients were followed for a median of 17.5 months during which three cardiac deaths occurred. Repeat revascularization was performed in 25% (<jats:italic>n<\/jats:italic>\u2009=\u20098). Overall mortality at maximum follow\u2010up was 47% (<jats:italic>n<\/jats:italic>\u2009=\u200926). The only significant predictor for hospital survival was left ventricular ejection fraction (odds ratio\u00a0[OR]: 1.10 (per 1 point increase); 95% confidence interval [CI]: 1.02\u20131.19; <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ULMCA occlusion carries a high short\u2010term mortality. Patients who survive index hospitalization have similar mortality rates as compared with other st elevation myocardial infarction\u00a0patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30585","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:05:45Z","timestamp":1676379945000},"page":"679-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical outcomes after unprotected left main coronary artery occlusion: A retrospective multicentre cohort analysis"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-0270","authenticated-orcid":false,"given":"Marco","family":"D\u00fcrig","sequence":"first","affiliation":[{"name":"Department of Cardiology University and Hospital Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Department of Cardiology University and Hospital Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bedossa","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Diseases University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Commeau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Polyclinique les Fleurs  Ollioules France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Barragan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Polyclinique les Fleurs  Ollioules France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Le Breton","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Diseases University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban","family":"Puricel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University and Hospital Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Cardiology University and Hospital Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01176-1"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"29","article-title":"Atherosclerotic and nonatherosclerotic coronary artery factors in acute myocardial infarction","volume":"20","author":"Waller BF","year":"1989","journal-title":"Cardiovasc Clin"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.5.823"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(16)30027-4"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"e18","article-title":"2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American college of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Lawton JS","year":"2022","journal-title":"Circulation"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I6A112"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03115-6"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"233","article-title":"Acute, total occlusion of the left main stem: coronary intervention options, outcomes, and recommendations","volume":"14","author":"\u00c9des IF","year":"2018","journal-title":"Adv\u00a0Interv\u00a0Cardiol"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(67)90023-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00874-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8238972"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.04.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5246504"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.4.1212"},{"issue":"11","key":"e_1_2_11_19_1","first-page":"621","article-title":"Primary angioplasty of unprotected left main coronary artery for acute anterolateral myocardial infarction","author":"Sakai K","year":"2004","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht529"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.037"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:03:54Z","timestamp":1692633834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/ccd.30585"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30585","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]},"assertion":[{"value":"2022-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}