{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:08:27Z","timestamp":1788304107968,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies comparing plug\u2010based (i.e., MANTA) with suture\u2010based (i.e., ProStar XL and ProGlide) vascular closure devices (VCDs) for large\u2010bore access closure after transcatheter aortic valve replacement (TAVR) have yielded mixed results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the comparative safety and efficacy of both types of VCDs among TAVR recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic database search was performed through March 2022 for studies comparing access\u2010site related vascular complications with plug\u2010based versus suture\u2010based VCDs for large\u2010bore access site closure after transfemoral (TF) TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies (2 randomized controlled trials\u00a0[RCTs] and 8 observational studies) with 3113 patients (MANTA\u2009=\u20091358, ProGlide\/ProStar XL\u2009=\u20091755) were included. There was no difference between plug\u2010based and suture\u2010based VCD in the incidence of access\u2010site major vascular complications (3.1% vs. 3.3%, odds ratio [OR]: 0.89; 95% confidence interval [CI]: 0.52\u22121.53). The incidence of VCD failure was lower in plug\u2010based VCD (5.2% vs. 7.1%, OR: 0.64; 95% CI: 0.44\u22120.91). There was a trend toward a higher incidence of unplanned vascular intervention in plug\u2010based VCD (8.2% vs. 5.9%, OR: 1.35; 95% CI: 0.97\u22121.89). Length of stay was shorter with MANTA. Subgroup analyses suggested significant interaction based on study designs such that there was higher incidence of access\u2010site vascular complications and bleeding events with plug\u2010based versus suture\u2010based VCD among RCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients undergoing TF\u2010TAVR, large\u2010bore access site closure with plug\u2010based VCD was associated with a similar safety profile as suture\u2010based VCD. However, subgroup analysis showed that plug\u2010based VCD was associated with higher incidence of vascular and bleeding complications in RCTs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30597","type":"journal-article","created":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T21:05:08Z","timestamp":1676840708000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcomes with plug\u2010based versus suture\u2010based vascular closure device after transfemoral transcatheter aortic valve replacement: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-0851","authenticated-orcid":false,"given":"Ramy","family":"Sedhom","sequence":"first","affiliation":[{"name":"Division of Cardiology Loma Linda University Health Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander 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