{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:53:21Z","timestamp":1773683601225,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about intravascular imaging predictors of cardiac events after drug\u2010eluting stent (DES) implantation in hemodialysis (HD) patients. We aimed to reveal the association between calcified nodules (CN) and target lesion failure (TLF) in HD patients after DES implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 114 HD patients who underwent DES implantation between October 2016 and October 2020. The patients were divided into a CN group (39%, 44 patients) and a non\u2010CN group (61%, 70 patients). The primary endpoint was the incidence of TLF, including cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HD duration was longer, and the calcium burden was higher in the CN group than in the non\u2010CN group. Over a median follow\u2010up of 607 days [interquartile range: 349\u2013965 days], the cumulative incidence curve showed that the CN group had a significantly higher incidence of TLF than the non\u2010CN group (31.8% vs. 11.4% within 3 years, <jats:italic>p<\/jats:italic>\u2009=\u20090.008).\u3000On Fine\u2010Gray sub\u2010distribution hazard model analysis, the CN group was associated with an increased rate of TLF (hazard ratio\u00a0[HR]: 2.86; 95% confidence interval\u00a0[CI]: 1.21\u20136.75, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). An in\u2010stent CN was observed in 73% of the lesions with target lesion revascularization in the CN group, whereas no in\u2010stent CN was observed in the non\u2010CN group (<jats:italic>p<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CN was an independent predictor of TLF in patients undergoing HD. In\u2010stent CN was an important cause of TLF after DES implantation in CN lesions in HD patients;\u00a0therefore, a different strategy should be considered for treating the lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30599","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T20:27:55Z","timestamp":1677184075000},"page":"701-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of calcified nodule on target lesion failure after stent implantation in hemodialysis patients"],"prefix":"10.1002","volume":"101","author":[{"given":"Yutaka","family":"Matsuhiro","sequence":"first","affiliation":[{"name":"Division of Cardiology Osaka Rosai Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-6421","authenticated-orcid":false,"given":"Tomoharu","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-0817","authenticated-orcid":false,"given":"Takayuki","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kansai Rosai Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka Rosai Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isamu","family":"Mizote","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka 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