{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:13:24Z","timestamp":1771643604700,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify a simple echocardiographic predictor of procedural success to select patient for percutaneous suture\u2010mediated patent fossa ovalis (PFO) closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous suture\u2010mediated PFO closure has been shown as a safe and advantageous alternative to device\u2010based PFO closure, yet its overall success is slightly lower in unselected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preprocedural transesophageal echocardiogram (TEE) of 302 patients (113 men, 45\u2009\u00b1\u200912 years) who underwent percutaneous suture\u2010mediated PFO closure were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At echocardiographic follow\u2010up (3\u20136 months), residual right\u2010to\u2010left shunt\u00a0(RLS) \u22652 was found in 60 (19.9%) patients. At multivariable analysis, only two anatomical variables measured at preprocedural TEE were found as independent predictors of residual RLS\u2009\u2265\u20092 at follow\u2010up: PFO maximum width\u00a0(odds ratio\u00a0[OR] 1.89, 95% confidence interval [CI] 1.16\u20133.40, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and PFO minimal septa overlapping (OR 0.58, 95% CI 0.35\u20130.88, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). An index based on the ratio of PFO maximum width to PFO minimum septal overlapping (W\/SO) proved to be the most powerful predictor of RLS\u2009\u2265\u20092 at follow\u2010up (OR 48.1, 95% CI 9.3\u2013352.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The ROC curve for the W\/SO ratio was found to have an AUC of 0.84 (95% CI 0.75\u20130.93) and a cut\u2010off value of 0.61 yielding a sensitivity of 80% and specificity of 78% with a negative predictive value of 94%. A decision tree methodology's AUC was 0.75 (95% CI 0.67\u20130.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study indicate that the ratio between the maximum amplitude of the PFO and the minimum overlap of the septa is the best predictive index of a favorable result by using one stitch only.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30604","type":"journal-article","created":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T06:24:06Z","timestamp":1677392646000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A new echocardiographic index to select patients for PFO suture\u2010mediated percutaneous closure"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-8463","authenticated-orcid":false,"given":"Achille","family":"Gaspardone","sequence":"first","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-7412","authenticated-orcid":false,"given":"Gregory A.","family":"Sgueglia","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gaspardone","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS San Raffaele Scientific Institute Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"De Santis","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"D'Ascoli","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Piccioni","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Iamele","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-2120","authenticated-orcid":false,"given":"Maria Benedetta","family":"Giannico","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Tarsia","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Sant'Eugenio Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Versaci","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia, Ospedale Santa Maria Goretti Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705915"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610057"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707404"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00023"},{"key":"e_1_2_7_6_1","volume-title":"Percutaneous Cardiac Interventions Textbook. Tips and Tricks of New Techniques Beyond Stenting","author":"Gaspardone A","year":"2019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018501"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.06.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.05.040"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24637"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664672"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28936"},{"key":"e_1_2_7_13_1","unstructured":"GaspardoneA CinqueA BeggioE et al. Percutaneous suture\u2010mediated Patent Fossa Ovalis (PFO) closure: two\u2010year clinical follow\u2010up. Minerva Cardiol\u00a0Angiol.\u00a0Published online June 17 2021.10.23736\/S2724-5683.21.05718-5"},{"key":"e_1_2_7_14_1","unstructured":"BeneduceA AnconaMB MoroniF et al. Suture\u2010mediated percutaneous patent foramen ovale closure: a systematic transesophageal echocardiography study. EuroIntervention. 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