{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:47:08Z","timestamp":1790822828566,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether the severity of calcification assessed by the peripheral artery calcification scoring system (PACSS) was associated with clinical outcomes of drug\u2010coated balloon (DCB) angioplasty for femoropopliteal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively analyzed 733 limbs with intermittent claudication of 626 patients, who underwent DCB angioplasty for de novo femoropopliteal lesions between January 2017 and February 2021 at seven\u00a0cardiovascular centers in Japan. The patients were categorized using the PACSS classification (grades 0\u20134: no visible calcification of the target lesion, unilateral wall calcification\u2009&lt;\u20095\u2009cm, unilateral calcification\u2009\u2265\u20095\u2009cm, bilateral wall calcification\u2009&lt;\u20095\u2009cm, and bilateral calcification\u2009\u2265\u20095\u2009cm, respectively). The main outcome was primary patency at 1 year. The Cox proportional hazards analysis was used to explore whether the PACSS classification was an independent predictor of clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of PACSS was grade 0 in 38%, grade 1 in 17%, grade 2 in 7%, grade 3 in 16%, and grade 4 in 23%. The 1\u2010year primary patency rates in these grades, respectively, were 88.2%, 89.3%, 71.9%, 96.5%, and 82.6%, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analysis disclosed that PACSS grade 4 (hazard ratio: 1.82, 95% confidence interval 1.15\u22122.87, <jats:italic>p<\/jats:italic>\u2009=\u20090.010) was associated with restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PACSS grade 4 calcification was independently associated with poor clinical outcomes after DCB angioplasty for de novo femoropopliteal lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30622","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T15:10:57Z","timestamp":1678288257000},"page":"892-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of calcification on clinical outcomes after drug\u2010coated balloon angioplasty for superficial femoral artery disease: Assessment using the peripheral artery calcification scoring system"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-867X","authenticated-orcid":false,"given":"Shinsuke","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama City Eastern Hospital  Kishiwada Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Diabetes Care Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6438","authenticated-orcid":false,"given":"Tatsuya","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center  Kishiwada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1913-6894","authenticated-orcid":false,"given":"Kazuki","family":"Tobita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shonan Kamakura General Hospital  Kishiwada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-2808","authenticated-orcid":false,"given":"Naoki","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Asahi General Hospital  Asahi Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Funabashi Municipal Medical Center  Kishiwada Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-7729","authenticated-orcid":false,"given":"Kazunori","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Sendai Kousei Hospital  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Saiseikai Central Hospital  Kishiwada Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama City Eastern Hospital  Kishiwada Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama City Eastern Hospital  Kishiwada Osaka 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results from the First\u2010in\u2010Human randomized study of the ranger paclitaxel\u2010coated balloon for femoropopliteal treatment","volume":"11","author":"Steiner S","year":"2018","journal-title":"JACC"},{"issue":"5","key":"e_1_2_8_16_1","first-page":"484","article-title":"Drug\u2010coated balloon treatment for femoropopliteal artery disease. 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