{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:54Z","timestamp":1740103854596,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010procedural aortic insufficiency (AI) continues to be prevalent following transcatheter aortic valve replacement (TAVR). While several studies have assessed the outcomes of moderate\u2010severe AI following TAVR, the incidence, predictors, and outcomes of mild AI remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature review was performed to identify studies reporting on mild AI following TAVR. The primary outcome was pooled incidence of post\u2010TAVR mild AI. Secondary outcomes included pooled incidence of mild AI at 30 days and long term. The pooled incidence of midterm mortality in patients with post\u2010TAVR mild AI was also evaluated. The random effect generalized linear mixed\u2010effects model with logit\u2010transformed proportions and Hartung\u2013Knapp adjustment was used to calculate pooled incidence rates. Meta\u2010regression was performed to identify predictors of mild AI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled analysis included 19,241 patients undergoing TAVR across 50 studies. The mean age of patients ranged from 73 to 85 years, and female patients ranged from 20.0% to 83.3%. The overall pooled incidence of post\u2010TAVR mild AI was 56.1% (95% confidence interval [CI] 0.31\u20130.64). The pooled incidence of mild AI at 30 days was 33.7% (95% CI 0.12\u20130.37). At mean follow\u2010up of 1.15 years, the pooled incidence of mild AI was 37.0% (95% CI 0.16\u20130.45). The overall pooled incidence of Midterm mortality (mean follow\u2010up 1.22 years) in patients with mild AI was 14.8% (95% CI 0.10\u20130.25). At meta\u2010regression, none of the explored variables correlated with a difference in mild AI incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In published studies to date, 50% of patients undergoing TAVR develop mild AI postoperatively. In 37% of patients, this persists in long term. Though the incidence of AI is likely improving with newer generation TAVR valves, the prevalence and outcomes of mild AI should be closely monitored as TAVR volume and indications expand to younger patients with long life expectancy. The long\u2010term outcomes of mild AI remain unclear. Further dedicated studies on post\u2010TAVR mild AI are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30674","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T19:24:43Z","timestamp":1683919483000},"page":"166-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-4685","authenticated-orcid":false,"given":"Irbaz","family":"Hameed","sequence":"first","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-8267","authenticated-orcid":false,"given":"Adham","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Akron General Akron Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Candelario","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumera","family":"Khan","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amudhan","family":"Kannan","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nida","family":"Latif","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Amabile","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnar","family":"Geirsson","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Surgery Yale School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.03.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.047"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.05.023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_8_1","unstructured":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. 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