{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:02:58Z","timestamp":1787317378744,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mitral valve transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) is an effective option for treatment of mitral regurgitation (MR). We previously reported favorable 2\u2010year outcomes for the PASCAL transcatheter valve repair system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We report 3\u2010year outcomes from the multinational, prospective, single\u2010arm CLASP study with analysis by functional MR\u00a0(FMR) and degenerative MR (DMR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with core\u2010lab determined MR\u2009\u2265\u20093+ were deemed candidates for M\u2010TEER by the local heart team. Major adverse events were assessed by an independent clinical events committee to 1 year and by sites thereafter. Echocardiographic outcomes were evaluated by the core laboratory to 3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study enrolled 124 patients, 69% FMR; 31% DMR (60% NYHA class III\u2010IVa, 100% MR\u2009\u2265\u20093+). The 3\u2010year Kaplan\u2212Meier estimate for survival was 75% (66% FMR; 92% DMR) and freedom from heart failure hospitalization (HFH) was 73% (64% FMR; 91% DMR), with 85% reduction in annualized HFH rate (81% FMR; 96% DMR) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). MR\u2009\u2264\u20092+ was achieved and maintained in 93% of patients (93% FMR; 94% DMR) and MR\u2009\u2264\u20091+ in 70% of patients (71% FMR; 67% DMR) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean left ventricular end\u2010diastolic volume (181\u2009mL at baseline) decreased progressively by 28\u2009mL [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001]. NYHA class I\/II was achieved in 89% of patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 3\u2010year results from the CLASP study demonstrated favorable and durable outcomes with the PASCAL transcatheter valve repair system in patients with clinically significant MR. These results add to the growing body of evidence establishing the PASCAL system as a valuable therapy for patients with significant symptomatic MR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.30686","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T14:24:35Z","timestamp":1683987875000},"page":"145-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Three\u2010year outcomes for transcatheter repair in patients with mitral regurgitation from the CLASP study"],"prefix":"10.1002","volume":"102","author":[{"given":"Konstantinos","family":"Spargias","sequence":"first","affiliation":[{"name":"Hygeia Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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