{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T04:31:37Z","timestamp":1752985897492,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Quantitative flow ratio (QFR) is a novel, software\u2010based method to evaluate the physiology of coronary lesions. The aim of this study was to compare QFR with the established invasive measurements of coronary blood flow using instantaneous wave\u2010free ratio (iFR) or resting full\u2010cycle ratio (RFR) in daily cathlab routine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>102 patients with stable coronary artery disease and a coronary stenosis of 40%\u221290% were simultaneously assessed with QFR and iFR or RFR. QFR\u2010computation was performed by two certified experts using the appropriate software (QAngio XA 3D 3.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QFR showed a significant correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.75, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) to iFR and RFR. The area under the receiver curve for all measurements was 0.93 (95% confidence interval, 0.87\u20130.98) for QFR compared to iFR or RFR. QFR based assessment required less time with a median of 501\u2009s (IQR 421\u2013659\u2009s) compared to iFR or RFR which required a median of 734\u2009s to obtain the result (IQR 512\u2013967\u2009s; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The median use of contrast medium was similar with 21\u2009mL (IQR 16\u201330\u2009mL) for the QFR\u2010based and 22\u2009mL (IQR 15\u201335\u2009mL) for the iFR\u2010 or RFR\u2010based diagnostic. QFR diagnostic required less radiation. The median dose area product for QFR was 307cGycm<jats:sup>2<\/jats:sup> (IQR 151\u2013429\u2009cGycm<jats:sup>2<\/jats:sup>) compared to 599\u2009cGycm<jats:sup>2<\/jats:sup> (IQR 345\u20131082\u2009cGycm<jats:sup>2<\/jats:sup>) for iFR or RFR, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QFR measurements of coronary artery blood flow correlate with iFR or RFR measurements and are associated with shorter procedure times and reduced radiation dose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30690","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T10:54:37Z","timestamp":1684320877000},"page":"91-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of quantitative flow ratio with instantaneous wave\u2010free ratio and resting full\u2010cycle ratio during daily routine in the 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