{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:19:53Z","timestamp":1780449593631,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data about the long\u2010term performance of new\u2010generation ultrathin\u2010strut drug\u2010eluting stents (DES) in challenging coronary lesions, such as left main (LM), bifurcation, and chronic total occlusion (CTO) lesions are scant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The international multicenter retrospective observational ULTRA study included consecutive patients treated from September 2016 to August 2021 with ultrathin\u2010strut (&lt;70\u2009\u00b5m) DES in challenging de novo lesions. Primary endpoint was target lesion failure (TLF): composite of cardiac death, target\u2010lesion revascularization (TLR), target\u2010vessel myocardial infarction (TVMI), or definite stent thrombosis (ST). Secondary endpoints included all\u2010cause death, acute myocardial infarction (AMI), target vessel revascularization, and TLF components. TLF predictors were assessed with Cox multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1801 patients (age: 66.6\u2009\u00b1\u200911.2 years; male: 1410 [78.3%]), 170 (9.4%) experienced TLF during follow\u2010up of 3.1\u2009\u00b1\u20091.4 years. In patients with LM, CTO, and bifurcation lesions, TLF rates were 13.5%, 9.9%, and 8.9%, respectively. Overall, 160 (8.9%) patients died (74 [4.1%]\u00a0from cardiac causes). AMI and TVMI rates were 6.0% and 3.2%, respectively. ST occurred in 11 (1.1%) patients while 77 (4.3%) underwent TLR. Multivariable analysis identified the following predictors of TLF: age, STEMI with cardiogenic shock, impaired left ventricular ejection fraction, diabetes, and renal dysfunction. Among the procedural variables, total stent length increased TLF risk (HR: 1.01, 95%\u00a0CI: 1\u22121.02 per mm increase), while intracoronary imaging reduced the risk substantially (HR: 0.35, 95%\u00a0CI: 0.12\u22120.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrathin\u2010strut DES showed high efficacy and satisfactory safety, even in patients with challenging coronary lesions. Yet, despite using contemporary gold\u2010standard DES, the association persisted between established patient\u2010 and procedure\u2010related features of risk and impaired 3\u2010year clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30696","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T09:45:30Z","timestamp":1685094330000},"page":"221-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictors of target lesion failure after treatment of left main, bifurcation, or chronic total occlusion lesions with ultrathin\u2010strut drug\u2010eluting coronary stents in the ULTRA registry"],"prefix":"10.1002","volume":"102","author":[{"given":"Ovidio","family":"de Filippo","sequence":"first","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0019-0273","authenticated-orcid":false,"given":"Francesco","family":"Bruno","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke H.","family":"Pinxterhuis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre University of Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"G\u0105sior","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences in Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7937","authenticated-orcid":false,"given":"Leor","family":"Perl","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center, Beilinson Hospital Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gaido","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ospedale Maria Vittoria Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Tuttolomondo","sequence":"additional","affiliation":[{"name":"Cardiology Unit, University Hospital of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2926-9428","authenticated-orcid":false,"given":"Antonio","family":"Greco","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliero Universitaria Policlinico \u201cG. Rodolico\u2010San Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Verardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ospedale Maggiore Carlo Alberto Pizzardi Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Lo Martire","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-3918","authenticated-orcid":false,"given":"Mario","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ospedale San Giovanni Bosco Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-0284","authenticated-orcid":false,"given":"Attilio","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Division of Cardiology University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Liccardo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Pieve Emanuele Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Caglioni","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero Universitaria Di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Gonz\u00e1lez Ferreiro","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro, Galicia Sur Health Research Institute (IISGS) Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Rodin\u00f2","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-3200","authenticated-orcid":false,"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Cardiology Department Azienda Ospedaliera Ordine Mauriziano Umberto I Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Maggiore della Carit\u00e0 Hospital University of Eastern Piedmont Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Borzillo","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-2917","authenticated-orcid":false,"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-9496","authenticated-orcid":false,"given":"Wojciech","family":"Wa\u0144ha","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-6087","authenticated-orcid":false,"given":"Bruno","family":"Casella","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline H.","family":"Ploumen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre University of Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Pyka","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences in Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8253","authenticated-orcid":false,"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center, Beilinson Hospital Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gagnor","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ospedale Maria Vittoria Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-9912","authenticated-orcid":false,"given":"Raffaele","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Division of Cardiology University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Raposeiras","family":"Roubin","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Alvaro Cunqueiro, Galicia Sur Health Research Institute (IISGS) Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliero Universitaria Policlinico \u201cG. Rodolico\u2010San Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Zocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre University of Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Conrotto","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano M.","family":"De Ferrari","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-2832","authenticated-orcid":false,"given":"Clemens","family":"von Birgelen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente Enschede The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre University of Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-9317","authenticated-orcid":false,"given":"Fabrizio","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department Division of Cardiology,\u00a0A. O. U. Citt\u00e0 della Salute e della Scienza Turin Italy"},{"name":"Department of Biomedical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ULTRA Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.097014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.23.2816"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcaa041"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26880"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.02.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.003210"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034456"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.02.019"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31920-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32467-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32249-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1157\/13084649"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.760"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.04.026"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy223"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.04.054"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-00766"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12516"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.05.044"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008325"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29368"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0001-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.02.015"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.037"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvz048"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003255"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.09.028"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28972"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa543"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006243"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.09.033"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.01.254"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T07:45:57Z","timestamp":1692344757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,26]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ccd.30696"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30696","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,26]]},"assertion":[{"value":"2023-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}