{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:51:14Z","timestamp":1767981074179,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Growing interest in neuroprotection in transcatheter aortic valve replacement (TAVR) has catalyzed the development of cerebral protection systems (CPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Report insights from consecutive real\u2010world patients undergoing TAVR with the Sentinel\u2010CPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with severe aortic stenosis undergoing TAVR from April 2019 to May 2022 were enrolled in a prospective registry. The reason for unsuccessful Sentinel\u2010CPS deployment and the amount of debris captured by the filters were prospectively recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Sentinal CPS was successfully deployed in 330 patients (85%, Group 1). Deployment was not attempted, unsuccessful or only partially successful in 59 patients (15%, Group 2), caused by anatomical factors such as tortuosity, heavy calcification or small dimensions of radial or brachial artery in 46, technical aspects such as puncture failure or dissection in 5 or use of right radial access for the pigtail in 6. Debris was captured in 98% of patients in Group 1. In 40%, the amount of debris was graded moderate or extensive. Predictors for moderate\/extensive debris were moderate\/severe aortic calcification (OR 1.50, CI 1.05\u20132.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), pre\u2010 and postdilatation (OR 1.97, CI 1.02\u20133.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.04 and OR 1.71, CI 1.01\u20132.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.048). The risk of stroke was numerically lower in patients who underwent TAVR with the Sentinel CPS (2.1 vs. 5.1%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.15). There was no stroke during CPS deployment, but one patient had a stroke immediately after device retrieval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Sentinel\u2010CPS was successfully deployed in 85% of patients. Predictors for moderate\/extensive debris captured were moderate\/severe aortic calcification, pre\u2010 and postdilatation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30697","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T10:54:27Z","timestamp":1685098467000},"page":"339-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral embolic protection during transcatheter aortic valve replacement: Insights from a consecutive series with the Sentinel cerebral protection device"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-0128","authenticated-orcid":false,"given":"Mathias","family":"Wolfrum","sequence":"first","affiliation":[{"name":"Heart Center Lucerne, Cardiology Division, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-5676","authenticated-orcid":false,"given":"Federico","family":"Moccetti","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Cardiology Division, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucca","family":"Loretz","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Cardiology Division, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Bossard","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Cardiology Division, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Attiger","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Cardiology Division, Luzerner Kantonsspital Lucerne 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of repositioning during transcatheter aortic valve replacement on embolized debris","volume":"31","author":"Seeger J","year":"2019","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.01.020"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.11.013"}],"container-title":["Catheterization and Cardiovascular 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