{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:10Z","timestamp":1786977370642,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between high postprocedural mean gradient (ppMG) and clinical events following mitral valve transcatheter edge\u2010to\u2010edge repair (MV\u2010TEER) in patients with degenerative mitral regurgitation (DMR) is still debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate the effect of elevated ppMG after MV\u2010TEER on clinical events in patients with DMR at 1\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 371 patients with DMR treated with MV\u2010TEER enrolled in the \u201cMulti\u2010center Italian Society of Interventional Cardiology (GISE) registry of trans\u2010catheter treatment of mitral valve regurgitation\u201d (GIOTTO) registry. Patients were stratified in tertiles according to ppMG. Primary endpoint was a composite of all\u2010cause death and hospitalization due to heart failure at 1\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were stratified as follows: 187 with a ppMG\u2009\u2264\u20093\u2009mmHg, 77 with a ppMG &gt;\u20093\/=4\u2009mmHg, and 107 with a ppMG\u2009&gt;\u20094\u2009mmHg. Clinical follow\u2010up was available in all subjects. At multivariate analysis, neither a ppMG\u2009&gt;\u20094\u2009mmHg nor a ppMG\u2009\u2265\u20095\u2009mmHg were independently associated with the outcome. Notably, the risk of elevated residual MR (rMR\u2009&gt;\u20092+) was significantly higher in patients belonging to the highest tertile of ppMG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). The association of ppMG\u2009&gt;\u20094\u2009mmHg and rMR\u2009\u2265\u20092+ was strongly and independently associated with adverse events (hazard ratio: 1.98; 95% confidence interval: [1.10\u20133.58]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a real\u2010world cohort of patients suffering DMR and treated with MV\u2010TEER, isolated ppMG was not associated with the outcome at 1\u2010year follow\u2010up. A high proportion of patients showed both elevated ppMG and rMR and their combination appeared to be a strong predictor of adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.30698","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T05:49:06Z","timestamp":1685080146000},"page":"310-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Postprocedural trans\u2010mitral gradient in patients with degenerative mitral regurgitation undergoing mitral valve transcatheter edge\u2010to\u2010edge repair"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-3006","authenticated-orcid":false,"given":"Francesco","family":"De Felice","sequence":"first","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9942-9162","authenticated-orcid":false,"given":"Carmine","family":"Musto","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Cifarelli","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-1003","authenticated-orcid":false,"given":"Silvio","family":"Coletta","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pennacchi","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Stio","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Grasso","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Centro Alte Specialit\u00e0 e Trapianti (CAST), Azienda Ospedaliero\u2010Universitaria Policlinico \u201cG. Rodolico \u2010 S. Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Centro Alte Specialit\u00e0 e Trapianti (CAST), Azienda Ospedaliero\u2010Universitaria Policlinico \u201cG. Rodolico \u2010 S. Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":false,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiology and Cardiac Catheterization, ASST Spedali Civili Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery San Raffaele University Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Giordano","sequence":"additional","affiliation":[{"name":"Invasive Cardiology Unit Pineta Grande Hospital, Castel Volturno Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De 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