{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:42Z","timestamp":1791410922282,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Women with atrial fibrillation (AF) generally experience worse symptoms, poorer quality of life, and have a higher risk of stroke and death. There is limited availability of sex\u2010related differences regarding left atrial appendage occlusion (LAAO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to evaluate the sex\u2010related differences in patients undergoing LAAO in EWOLUTION.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1025 patients scheduled for elective LAAO therapy employing the WATCHMAN Gen 2.5 prospectively consented for participation; 1005 patients received a successful implant and were followed for 2 years. As we detected sex\u2010related differences in baseline data we performed a propensity score matching. The primary endpoint is a combined endpoint of survival free from mortality, major bleeding, ischemic stroke, transitory ischemic attack (TIA) and systemic embolization (SE) up to 2\u2010year clinical follow\u2010up. Secondary Endpoints were periprocedural data and overall 2\u2010year survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women were older but had less often vascular disease and hemorrhagic stroke. There was no sex\u2010related significant difference after LAAO at 2 years in the combined endpoint of survival free from mortality, major bleeding, ischemic stroke, TIA, and SE (female vs. male: 79% vs.76%, <jats:italic>p<\/jats:italic>\u2009=\u20090.24) or in overall survival (female vs. male: 85% vs. 82%, <jats:italic>p<\/jats:italic>\u2009=\u20090.16). Procedural data showed a higher sealing rate after the implantation in women (complete sealing female 94% vs. male 90%, <jats:italic>p<\/jats:italic>\u2009=\u20090.033), significantly more pericardial effusions (female 1.2% vs. male 0.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) and a similar periprocedural risk profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Females undergoing LAAO differ in various baseline variables, but after adjustment, we observed similar safety and efficacy of LAAO with no significant difference in long\u2010term outcomes between women and men.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30759","type":"journal-article","created":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T11:58:58Z","timestamp":1688299138000},"page":"283-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex\u2010related differences in outcome after left atrial appendage occlusion: Insights from Europe and the EWOLUTION registry"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-9693","authenticated-orcid":false,"given":"Christina","family":"Paitazoglou","sequence":"first","affiliation":[{"name":"University Heart Center L\u00fcbeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine) University Schleswig\u2010Holstein (UKSH)"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\u2010Kiel\u2010L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"University Heart Center L\u00fcbeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine) University Schleswig\u2010Holstein (UKSH)"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\u2010Kiel\u2010L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[{"name":"University Heart Center L\u00fcbeck, Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine) University Schleswig\u2010Holstein (UKSH)"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\u2010Kiel\u2010L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hueseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Vivantes Klinikum Neuk\u00f6lln and Klinikum Am Urban Berlin Germany"},{"name":"Department of Cardiology University Rostock  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kische","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vivantes Klinikum im Friedrichshain Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Pokushalov","sequence":"additional","affiliation":[{"name":"Department of Cardiology E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Elisabeth Krankenhaus Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-9906","authenticated-orcid":false,"given":"Boris","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Cardiology Universit\u00e4tsmedizin Mainz und DZHK Standort Rhein\u2010Main Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-8444","authenticated-orcid":false,"given":"Felix","family":"Meincke","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik Altona Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Vireca","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Diegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wohlmuth","sequence":"additional","affiliation":[{"name":"ASKLEPIOS proresearch Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boersma","family":"Lucas","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital Nieuwegein The Netherlands"},{"name":"Amsterdam UMV Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin 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