{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:12:18Z","timestamp":1776755538016,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a paucity of data regarding the comparative efficacy and safety of Mitral valve transcatheter edge\u2010to\u2010edge repair (MTEER) using the PASCAL or MitraClip systems for patients with mitral regurgitation (MR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic search was conducted for MEDLINE, COCHRANE, and EMBASE, through February 2023, for studies comparing the clinical outcomes of MTEER using PASCAL versus MitraClip systems among patients with severe MR. The primary study outcome was residual MR\u2009\u2264\u20092 at discharge. Data were pooled using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final analysis included six studies with a total of 1581 patients, with a weighted follow\u2010up period of 3.5 months. Two studies only included patients with degenerative MR, while the remaining studies included both degenerative and functional MR. There was no significant difference in procedure duration between MTEER with the PASCAL or MitraClip systems. There was no difference in residual MR\u2009\u2264\u20092 at discharge (94.7% vs. 91.9%; odds ratio [OR]: 1.44; 95% confidence interval [CI]: 0.92\u20132.27) or residual MR\u2009\u2264\u20092 at the mid\u2010term follow\u2010up (94.6% vs. 91.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.05) among the PASCAL versus MitraClip systems. There was no difference between both groups in residual MR\u2009\u2264\u20091 at discharge (73.1% vs. 63.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.12), while there was greater incidence of residual MR\u2009\u2264\u20091 at midterm follow\u2010up with the PASCAL system (71.3% vs. 56.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no difference between the PASCAL and MitraClip MTEER systems in technical success (97.0% vs. 97.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.15), procedural success (89.1% vs. 87.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.78), single leaflet detachment (1.8% vs. 1.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.55), or all\u2010cause mortality (3.6% vs. 4.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this meta\u2010analysis, we demonstrated comparable efficacy and safety between the PASCAL and MitraClip MTEER systems at short\u2010 and mid\u2010term assessments. Randomized trials are warranted to evaluate the comparative long\u2010term outcomes between both MTEER systems.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30772","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:20:15Z","timestamp":1690377615000},"page":"521-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter edge\u2010to\u2010edge repair for mitral regurgitation using PASCAL or MitraClip"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-781X","authenticated-orcid":false,"given":"Ayman","family":"Elbadawi","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander T.","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Medical Branch Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-0394","authenticated-orcid":false,"given":"Mohamed","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Florida Atlantic University Boca Raton Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-349X","authenticated-orcid":false,"given":"Abdelrahman","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Department of Cardiology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-8030","authenticated-orcid":false,"given":"Marwan","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2019 Division of Cardiology, Alpert Medical School of Brown University Lifespan Cardiovascular Institute Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-358X","authenticated-orcid":false,"given":"Hani","family":"Jneid","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Medical Branch Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan K.","family":"Chhatriwalla","sequence":"additional","affiliation":[{"name":"Division of Cardiology Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-3876","authenticated-orcid":false,"given":"Sachin","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Houston Methodist Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethi","family":"Mani","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Bavry","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-4538","authenticated-orcid":false,"given":"Dharam J.","family":"Kumbhani","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.09.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa062"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.121.010895"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13849"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_8_1","first-page":"366","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"14898","author":"Sterne JA","year":"2019","journal-title":"BMJ"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.02.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-021-01845-8"},{"key":"e_1_2_8_12_1","first-page":"2541\u20102551","article-title":"Early outcomes of 2 mitral valve transcatheter leaflet approximation devices: a propensity score\u2013matched multicenter comparison","volume":"24","author":"Mauri V","year":"2022","journal-title":"JACC Cardiovasc Intervent"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.10.028"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.05.021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00558-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31600-8"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:05:06Z","timestamp":1697079906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ccd.30772"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30772","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]},"assertion":[{"value":"2023-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}