{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:07:47Z","timestamp":1785150467360,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of intracoronary imaging on outcomes, after provisional versus dual\u2010stenting for bifurcation left main (LM) lesions, is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the effect of intracoronary imaging in the EBC MAIN trial (European Bifurcation Club LM Coronary Stent study).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four hundred and sixty\u2010seven\u00a0patients were randomized to dual\u2010stenting or a stepwise provisional strategy. Four hundred and fifty\u2010five\u00a0patients were included. Intravascular ultrasound (IVUS) or optical coherence tomography (OCT) was undertaken at the operator's discretion. The primary endpoint was death, myocardial infarction or target vessel revascularization at 1\u2010year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intracoronary imaging was undertaken in 179 patients (39%; IVUS\u2009=\u2009151, OCT\u2009=\u200928). As a result of IVUS findings, operators reintervened in 42 procedures. The primary outcome did not differ with intracoronary imaging versus angiographic\u2010guidance (17% vs. 16%; odds ratio [OR]: 0.92 (95% confidence interval [CI]: 0.51\u22121.63)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.767), nor for reintervention based on IVUS versus none (14% vs. 16%; OR: 0.88 [95% CI: 0.32\u22122.43]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.803), adjusted for syntax score, lesion calcification and ischemic symptoms. With angiographic\u2010guidance, primary outcome events were more frequent with dual versus provisional stenting (21% vs. 10%; adjusted OR: 2.11 [95% CI: 1.04\u22124.30]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). With intracoronary imaging, there were numerically fewer primary outcome events with dual versus provisional stenting (13% vs. 21%; adjusted OR: 0.56 [95% CI: 0.22\u22121.46]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.220).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In EBC MAIN, the primary outcome did not differ with intracoronary imaging versus none. However, in patients with angiographic\u2010guidance, outcomes were worse with a dual\u2010stent than provisional strategy When intracoronary imaging was used, there was a trend toward better outcomes with the dual\u2010stent than provisional strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.30785","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:06:10Z","timestamp":1689872770000},"page":"415-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bifurcation left main stenting with or without intracoronary imaging: Outcomes from the EBC MAIN trial"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-5153","authenticated-orcid":false,"given":"Annette","family":"Maznyczka","sequence":"first","affiliation":[{"name":"Leeds General Infirmary Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Arunothayaraj","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-318X","authenticated-orcid":false,"given":"Mohaned","family":"Egred","sequence":"additional","affiliation":[{"name":"Freeman Hospital Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Banning","sequence":"additional","affiliation":[{"name":"John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brunel","sequence":"additional","affiliation":[{"name":"Hopital Prive Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslaw","family":"Ferenc","sequence":"additional","affiliation":[{"name":"Universitats\u2010Herzzentrum Bad Krozingem Bad Krozingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hovasse","sequence":"additional","affiliation":[{"name":"Institute Cardiovasculaire Paris Sud Massy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Wlodarczak","sequence":"additional","affiliation":[{"name":"Poland Miedziowe Centrum Zdrowia Lubin Lubin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Reina Sofia Hospital, (IMIBIC) University of Cordoba Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Elisabeth Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Clinique Axium Aix en Provence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-0182","authenticated-orcid":false,"given":"Andrejs","family":"Erglis","sequence":"additional","affiliation":[{"name":"Paul Stradins University hospital Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Kretov","sequence":"additional","affiliation":[{"name":"Sibirsky Federal Biomedical Research Center Novosibrisk  Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Flensted","family":"Lassen","sequence":"additional","affiliation":[{"name":"Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaide","family":"Chieffo","sequence":"additional","affiliation":[{"name":"\u00b0San Raffaele Sciientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lefevre","sequence":"additional","affiliation":[{"name":"Institute Cardiovasculaire Paris Sud Massy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Genelli Universita Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cockburn","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Darremont","sequence":"additional","affiliation":[{"name":"Clinique Saint\u2010Augustin\u2010Elsan Bordeux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Departmenet of Cardiology, Clinical Centre of Serbia University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claude","family":"Morice","sequence":"additional","affiliation":[{"name":"Institute Cardiovasculaire Paris Sud Massy 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