{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:54:49Z","timestamp":1764557689027,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited national\u2010level data on the contemporary practices of mechanical circulatory support (MCS) use in acute myocardial infarction\u2010cardiogenic shock (AMI\u2010CS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized the Healthcare Cost and Utilization Project\u2010National\/Nationwide Inpatient Sample\u00a0data (2005\u20132017) to identify adult admissions (&gt;18 years) with AMI\u2010CS. MCS devices were classified as intra\u2010aortic balloon pump (IABP), percutaneous left ventricular assist devices (pLVAD), or extracorporeal membrane oxygenation (ECMO). We evaluated trends in the initial device used (IABP alone, pLVAD alone or \u22652 MCS devices), device escalation, bridging to durable LVAD\/heart transplantation, and predictors of in\u2010hospital mortality and device escalation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 327,283 AMI\u2010CS admissions, 131,435 (40.2%) had an MCS device placed with available information on timing of placement. IABP, pLVAD, and \u22652 MCS devices were used as initial device in 120,928 (92.0%), 8202 (6.2%), and 2305 (1.7%) admissions, respectively. Most admissions were maintained on the initial MCS device with 1%\u20131.5% being escalated (IABP to pLVAD\/ECMO, pLVAD to ECMO). Urban, medium, and large\u2010sized hospitals and acute multiorgan failure were significant independent predictors of MCS escalation. In admissions receiving MCS, escalation of MCS device was associated with higher in\u2010hospital mortality (adjusted odds ratio:\u00a01.56, 95% confidence interval:\u00a0\u00a01.38\u20131.75; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Admissions receiving durable LVAD\/heart transplantation increased over time in those initiated on pLVAD and \u22652 MCS devices, resulting in lower in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this 13\u2010year study, escalation of MCS in AMI\u2010CS was associated with higher in\u2010hospital mortality suggestive of higher acuity of illness. The increase in number of durable LVAD\/heart transplantations alludes to the role of MCS as successful bridge strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30786","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T21:04:53Z","timestamp":1689887093000},"page":"403-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Escalation strategies, management, and outcomes of acute myocardial infarction\u2010cardiogenic shock patients receiving percutaneous left ventricular support"],"prefix":"10.1002","volume":"102","author":[{"given":"Sri Harsha","family":"Patlolla","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-6029","authenticated-orcid":false,"given":"Olivia 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