{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:45:38Z","timestamp":1780332338246,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the impact of tricuspid regurgitation (TR) on echocardiographic and functional outcome after mitral valve transcatheter edge\u2010to\u2010edge\u2010repair (M\u2010TEER).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A total of 740 patients underwent M\u2010TEER at our center from 2010 to 2021. Patients were analyzed according to severity of concomitant TR at the time of M\u2010TEER procedure: low\u2010grade TR (grade \u2264I [trace\u2013mild], 279 patients [37.7%]), moderate TR (grade II, 170 patients [23.0%]) and high\u2010grade TR (grade III\u2010V [severe\u2013torrential], 291 patients [39.3%]). Patients with moderate to high\u2010grade TR had higher morbidity. Procedural success of M\u2010TEER was achieved similarly in all groups (98.2% vs. 97.6% vs. 95.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.22). TR severity decreased rapidly and consistently after M\u2010TEER to only 48.0% of high\u2010grade TR patients after 3 months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and to 46.8% after 12 months (<jats:italic>p<\/jats:italic>\u2009=\u20090.99). High\u2010grade TR patients had significantly higher mortality (21.5% vs. 18.2% vs. 11.1%,\u00a0<jats:italic>p<\/jats:italic>\u2009=\u20090.003) up to 12 months after M\u2010TEER. However, high\u2010grade TR did not independently predict mortality (HR 1.302, 95% CI 0.937\u20131.810; <jats:italic>p<\/jats:italic>\u2009=\u20090.116). Echocardiographic and functional outcome was similar in both secondary and primary MR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010grade concomitant TR did not independently predict adverse outcome following\u00a0M\u2010TEER. A wait\u2010and\u2010observe approach for these patients is reasonable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30787","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T17:28:15Z","timestamp":1690565295000},"page":"528-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of concomitant tricuspid regurgitation on outcome after edge\u2010to\u2010edge mitral valve repair"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-3901","authenticated-orcid":false,"given":"Matthias","family":"Gr\u00f6ger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II Ulm University Hospital Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina P.","family":"Zeiml","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Ulm University Hospital Ulm 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