{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:36:50Z","timestamp":1775083010431,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conduction disturbances requiring permanent pacemaker implantation (PPI) are common following transcatheter aortic valve replacement (TAVR). There were conflicting data regarding the impact of new PPI on clinical outcomes after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study sought to evaluate the impact of new PPI on clinical outcomes in patients undergoing TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective analysis of prospectively collected data. Data were from 210 consecutive patients without prior PPI who underwent TAVR due to severe symptomatic aortic stenosis at our center between June 2018 and July 2020. Clinical, echocardiographic, and pacing data were assessed at 30\u2010day, 1\u2010 and 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>New PPI was required in 35 (16.7%) patients within 30 days after TAVR. The median time from TAVR to PPI was 3 days. The most common indication for PPI was high\u2010degree or complete atrioventricular block. The median follow\u2010up was 798.0 (interquartile range, 669.0\u20131115.0) days. There were no differences in all\u2010cause mortality (adjusted hazard ratio [HR]: 1.18; 95% confidence interval [CI]: 0.85\u20132.36; <jats:italic>p<\/jats:italic>\u2009=\u20090.415) and cardiovascular mortality (adjusted HR: 0.92; 95% CI: 0.57\u20131.89; <jats:italic>p<\/jats:italic>\u2009=\u20090.609) between groups. However, PPI group had a higher risk of heart failure (HF) rehospitalization (adjusted HR: 1.53; 95% CI: 1.26\u20132.28; <jats:italic>p<\/jats:italic>\u2009=\u20090.027). Echocardiography showed no significant improvement of LVEF over time in patients with PPI. At the latest follow\u2010up, 31.3% of patients exhibited low (\u226410%) pacing burdens, whereas 28.1% of patients had near constant (&gt;90%) right ventricular pacing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>New PPI within 30 days following TAVR was not associated with an increased risk of all\u2010cause or cardiovascular mortality. However, patients with PPI had a higher risk of HF rehospitalization and lack of LVEF improvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30788","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:23:57Z","timestamp":1690377837000},"page":"743-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic impact of new permanent pacemaker implantation following transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"102","author":[{"given":"Hua\u2010Jie","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Southwest Hospital Third Military Medical University (Army Medical University) Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Southwest Hospital Third Military Medical University 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