{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:29:49Z","timestamp":1770740989687,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T00:00:00Z","timestamp":1691280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>New\u2010generation drug\u2010eluting stents (DES) achieved technological innovations and reported clinical advantages as compared with first\u2010generation DES in clinical trials with 3\u20135 years follow\u2010up. However, detailed clinical outcome data in very long\u2010term follow\u2010up is still scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate 10\u2010year clinical outcomes after first\u2010 and new\u2010generation DES implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this extende follow\u2010up study of the RESET, which is a largest randomized trial comparing everolimus\u2010eluting stent (EES) with Sirolimus\u2010eluting stent (SES), the study population consisted of 2892 patients from 84 centers. The primary efficacy and safety endpoints were target lesion revascularization (TLR) and a composite of death or myocardial infarction (MI), respectively. Complete 10\u2010year follow\u2010up was achieved in 87.9% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative 10\u2010year incidences of TLR and non\u2010TLR were not significantly different between EES and SES (13.9% vs. 15.7%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.20, and 33.4% vs. 31.3%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.30). The cumulative 10\u2010year incidence of death\/MI was also not significantly different between the groups (32.5% vs. 34.4%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.18). Cumulative 10\u2010year incidence of definite stent thrombosis was numerically lower in EES than in SES (1.0% vs. 1.7%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.16). The lower risk of EES relative to SES was significant for a composite endpoint of target lesion failure (TLF: 19.6% vs. 24.9%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and target vessel failure (TVF: 26.7% vs. 31.4%, Log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During 10\u2010year\u00a0of follow\u2010up, the risks for primary efficacy and safety endpoints were not significantly different between new\u2010generation EES and first\u2010generation SES, although EES compared with SES was associated with a lower risk for composite endpoints such as TLF and TVF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30791","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:34:09Z","timestamp":1691390049000},"page":"594-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ten\u2010year clinical outcomes from a randomized trial comparing new\u2010generation everolimus\u2010eluting stent versus first\u2010generation Sirolimus\u2010eluting stent: Results from the RESET extended study"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-023X","authenticated-orcid":false,"given":"Hiroki","family":"Shiomi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto 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