{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:51:36Z","timestamp":1751377896329,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute myocardial infarction complicated by cardiogenic shock (AMI\u2010CS) is the most common cause of mortality following AMI, and treatment algorithms vary widely. We report the results of an analysis using time\u2010sensitive, hemodynamic goals in the treatment of AMI\u2010CS in a single center study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with AMI\u2010CS from November 2016 through December 2021 were included in our retrospective analysis. Clinical characteristics and outcomes were analyzed using the electronic medical records. We identified 63 total patients who were admitted to our center with AMI\u2010CS, and we excluded patients who did not have clear timing of AMI onset or CS onset. We evaluated the rate of survival to hospital discharge based on the quantity of certain time\u2010sensitive hemodynamic goals were met.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 63 patients who met criteria for AMI\u2010CS, 39 (62%) of whom survived to hospital discharge. Odds of survival were closely related to the achievement of four time\u2010dependent goals: cardiac power output (CPO) &gt;0.6 Watts (W), pulmonary artery pulsatility index (PAPi) &gt;1, lactate &lt;4\u2009mmol\/L, and &lt;2 vasopressors required. Of the 63 total patients, 36 (57%) received intra\u2010aortic balloon pump (IABP) and 18 (29%) received an Impella CP (Abiomed) as an initial mechanical circulatory support strategy. Six patients were escalated from IABP to Impella CP for additional hemodynamic support. Nine patients were treated with vasopressors\/inotropes alone. Regarding the 39 patients who survived to hospital discharge, 75% of patients met 3 or 4 goals at 24\u2009h, whereas only 16% of deceased patients met 3 or 4 goals at 24\u2009h. Of the 24 patients who did not survive to hospital discharge, 18 (75%) met either 0\u20131 goal at 24\u2009h. There was no effect of the initial treatment strategy on achieving 3\u20134 goals at 24\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study evaluated the association of meeting 4 time\u2010sensitive goals (CPO &gt;0.6\u2009W, PAPi &gt;1, &lt;2 vasopressors, and lactate &lt;4\u2009mmol\/L) at 24\u2009h after treatment for AMI\u2010CS with in\u2010hospital mortality. Our data show, in line with previous data, that the higher number of goals met at 24\u2009h was associated with improved in\u2010hospital mortality regardless of treatment strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30792","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T08:55:52Z","timestamp":1691398552000},"page":"569-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A goal\u2010oriented hemodynamic approach to acute myocardial infarction complicated by cardiogenic shock\u2014A single center experience"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-9979","authenticated-orcid":false,"given":"Vince","family":"Siebert","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-4494","authenticated-orcid":false,"given":"Jake","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Medicine Stritch School of Medicine, Loyola University Chicago Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-3623","authenticated-orcid":false,"given":"John","family":"Lopez","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Darki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lowell","family":"Steen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5860-4585","authenticated-orcid":false,"given":"Demetrios","family":"Doukas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiology Loyola University Medical Center Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz363"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2018.11.014"},{"issue":"16","key":"e_1_2_7_4_1","first-page":"e232","article-title":"American Heart Association Council on clinical cardiology; council on cardiovascular and stroke nursing; council on quality of care and outcomes research; and mission: lifeline. 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