{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T16:24:14Z","timestamp":1793982254073,"version":"4.8.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aortic regurgitation (AR) is associated with morbidity and premature mortality. Surgical aortic valve replacement is not an option for many patients due to an adverse surgical risk profile, whilst transcatheter aortic valve implantation with most available prostheses has demonstrated suboptimal implantation success and outcomes. The JenaValve Trilogy\u2122 system provides an attractive solution for such patients as it utilizes clips that directly attach onto the native valve leaflets to anchor. Initially designed for transapical delivery, the current transfemoral delivery system is under investigation in the United States and approved for aortic stenosis and regurgitation in Europe. We present an expert review on the technical aspects of the Trilogy system, provide a guide for implantation, discuss the available evidence for the technology and provide illustrative case examples.<\/jats:p>","DOI":"10.1002\/ccd.30795","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T08:32:28Z","timestamp":1691656348000},"page":"766-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A heart valve dedicated for aortic regurgitation: Review of technology and early clinical experience with the transfemoral Trilogy system"],"prefix":"10.1002","volume":"102","author":[{"given":"Andreas","family":"Baumbach","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute Queen Mary University of London London UK"},{"name":"Barts Heart Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-8128","authenticated-orcid":false,"given":"Kush P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Barts Heart Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kennon","sequence":"additional","affiliation":[{"name":"Barts Heart Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"Ozkor","sequence":"additional","affiliation":[{"name":"Barts Heart Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute Queen Mary University of London London UK"},{"name":"Barts Heart Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank\u00a0de la","family":"Huerta","sequence":"additional","affiliation":[{"name":"JenaValve Technology, Inc. Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Tamm","sequence":"additional","affiliation":[{"name":"Department of Cardiology,\u00a0Cardiology I University Medical Centre of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw229"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivab046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.4.1625"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90450-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2021.1988779"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.01.041"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.14.1851"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.07.141"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.04.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.006"},{"key":"e_1_2_8_15_1","unstructured":"TammA.JenaValve Trilogy Heart Valve System.Transcatheter Ther. Boston USA.2022."},{"key":"e_1_2_8_16_1","volume-title":"JenaValve ALIGN\u2010AR Pivotal Trial","year":"2020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2021.08.026"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00596"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:34:44Z","timestamp":1696534484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/ccd.30795"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30795","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,10]]},"assertion":[{"value":"2023-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}