{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:51:54Z","timestamp":1792713114173,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T00:00:00Z","timestamp":1691280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency or ultrasound renal denervation (RDN) has shown conflicting results when used as an adjunctive option for hypertension management in randomized controlled trials (RCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Pubmed, MEDLINE, and other online databases for RCTs comparing RDN versus sham\u2010control procedures in patients with uncontrolled or resistant hypertension. The endpoints of interest were 24\u2010h ambulatory (AMB) blood pressure (BP), daytime AMB BP, and office BP. We performed a random\u2010effects meta\u2010analysis using the inverse variance method to estimate mean difference (MD) with a 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies with 1643 patients were included in the final analysis. The mean follow\u2010up was 5 months. As compared with the sham\u2010controlled group, RDN was associated with a significant decrease in 24\u2010h AMB BP (systolic [MD \u22124.20; 95% CI \u22125.36 to \u22123.03; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001], diastolic [\u22122.38; \u22123.42 to \u22121.35]), and daytime AMB BP (systolic: \u22125.11; \u22126.75 to \u22123.47, diastolic: \u22122.88; \u22123.91 to \u22121.85). Similarly, office BP was reduced with RDN (systolic: \u22125.46; \u22127.12 to \u22123.81; diastolic: \u22123.17; \u22124.23 to \u22122.12) when compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis shows that RDN is associated with a significant reduction in the 24\u2010h AMB BP, daytime AMB BP, and office BP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30796","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:33:05Z","timestamp":1691389985000},"page":"663-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Renal denervation in hypertension: An updated meta\u2010analysis of the randomized controlled trials"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-782X","authenticated-orcid":false,"given":"Sahib","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine Sinai Hospital of Baltimore Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Rout","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-0851","authenticated-orcid":false,"given":"Aakash","family":"Garg","sequence":"additional","affiliation":[{"name":"Cardiology Associates of Schenectady St. Peter's Health Partners New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06487"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14240"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI100652"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62039-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.163014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2013.840445"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05283"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402670"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.058"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad054"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0713"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_15_1","unstructured":"Review 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