{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:18:06Z","timestamp":1785449886244,"version":"3.56.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bicuspid aortic valve (BAV) is present in approximately 0.5%\u20132% of the general population, causing significant aortic stenosis (AS) in 12%\u201337% of affected individuals. Transcatheter aortic valve replacement (TAVR) is being considered the treatment of choice in patients with symptomatic AS across all risk spectra.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Aim Our study aims to compare TAVR outcomes in patients with BAV versus tricuspid aortic valves (TAV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was performed in PubMed, Web of Science, and Cochrane trials. Studies were included if they included BAV and TAV patients undergoing TAVR with quantitative data available for at least one of our predefined outcomes. Meta\u2010analysis was performed by the random\u2010effects model using Stata software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty studies of 203,288 patients were included. BAV patients had increased 30\u2010day all\u2010cause mortality (odds ratio [OR]\u2009=\u20091.23 [1.00\u20131.50], <jats:italic>p<\/jats:italic>\u2009=\u20090.05), in\u2010hospital stroke (OR\u2009=\u20091.39 [1.01\u20131.93], <jats:italic>p<\/jats:italic>\u2009=\u20090.05), in\u2010hospital and 30\u2010day PPI (OR\u2009=\u20091.13 [1.00\u20131.27], <jats:italic>p<\/jats:italic>\u2009=\u20090.04; OR\u2009=\u20091.16 [1.04\u20131.13], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and in\u2010hospital, 30\u2010day and 1\u2010year aortic regurgitation (AR) (OR\u2009=\u20091.48 [1.19\u20131.83], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; OR\u2009=\u20091.79 [1.26\u20132.52], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; OR\u2009=\u20091.64 [1.03\u20132.60], <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Subgroup analysis on new\u2010generation valves showed a reduced 1\u2010year all\u2010cause mortality (OR\u2009=\u20090.86 [CI\u2009=\u20090.75\u20130.98], <jats:italic>p<\/jats:italic>\u2009=\u20090.03), despite higher in\u2010hospital and 30\u2010day PPI (OR\u2009=\u20090.1.21 [1.04\u20131.41], <jats:italic>p<\/jats:italic>\u2009=\u20090.01; OR\u2009=\u20091.17 [1.05\u20131.31], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and in\u2010hospital AR (OR\u2009=\u20091.62 [1.14\u20132.31], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) in the BAV group. The quality of included studies was moderate\u2010to\u2010high, and only three analyses presented high heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAVR is associated with comparable outcomes in patients with BAV and TAV. Careful selection of BAV cases by preprocedural assessment of valve anatomy and burden of calcification, pre\u2010 and post\u2010procedural dilation, and implementing newer generations of valves may improve the safety and efficacy of TAVR in BAV patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30808","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:56:35Z","timestamp":1692690995000},"page":"721-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes and the impact of valve morphology for transcatheter aortic valve replacement in bicuspid aortic valves: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-2119","authenticated-orcid":false,"given":"Rahul","family":"Gupta","sequence":"first","affiliation":[{"name":"Lehigh Valley Heart Institute Lehigh Valley Health Network Allentown Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Universal Scientific Education and Research Network Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-4227","authenticated-orcid":false,"given":"Amir Hossein","family":"Behnoush","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaqib H.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westchester Medical Center and New York Medical College Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Medicine Carle Foundation Hospital Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muling","family":"Lin","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0709-4324","authenticated-orcid":false,"given":"Dhrubajyoti","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westchester Medical Center and New York Medical College Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westchester Medical Center and New York Medical College Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandipan","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westchester Medical Center and New York Medical College Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya K.","family":"Aedma","sequence":"additional","affiliation":[{"name":"Department of Medicine Carle Foundation Hospital Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh Bala","family":"Gupta","sequence":"additional","affiliation":[{"name":"Guru Nanak Dev Hospital, Department of medicine Government Medical College Amritsar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurva V.","family":"Vyas","sequence":"additional","affiliation":[{"name":"Lehigh Valley Heart Institute Lehigh Valley Health Network Allentown Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Combs","sequence":"additional","affiliation":[{"name":"Lehigh Valley Heart Institute Lehigh Valley Health Network Allentown Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Mathur","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute Penn State Health, Milton S. 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