{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:37:03Z","timestamp":1788439023678,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severely calcified coronary lesions present a particular challenge for percutaneous coronary intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this randomized study was to determine whether coronary intravascular lithotripsy (IVL) is non\u2010inferior to rotational atherectomy (RA) regarding minimal stent area (MSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The randomized, prospective non\u2010inferiority ROTA.shock trial enrolled 70 patients between July 2019 and November 2021. Patients were randomly (1:1) assigned to undergo either IVL or RA before percutaneous coronary intervention of severely calcified coronary lesions. Optical coherence tomography was performed at the end of the procedure for primary endpoint analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary endpoint MSA was lower but non\u2010inferior after IVL (mean: 6.10\u2009mm<jats:sup>2<\/jats:sup>, 95% confidence interval [95% CI]: 5.32\u20136.87\u2009mm<jats:sup>2<\/jats:sup>) versus RA (6.60\u2009mm<jats:sup>2<\/jats:sup>, 95% CI: 5.66\u20137.54\u2009mm<jats:sup>2<\/jats:sup>; difference in MSA: \u22120.50\u2009mm<jats:sup>2<\/jats:sup>, 95% CI: \u22121.52\u20130.52\u2009mm<jats:sup>2<\/jats:sup>; non\u2010inferiority margin: \u22121.60\u2009mm<jats:sup>2<\/jats:sup>). Stent expansion was similar (RA: 0.83\u2009\u00b1\u20090.10 vs. IVL: 0.82\u2009\u00b1\u20090.11; <jats:italic>p<\/jats:italic>\u2009=\u20090.79). There were no significant differences regarding contrast media consumption (RA: 183.1\u2009\u00b1\u200968.8 vs. IVL: 163.3\u2009\u00b1\u200955.0\u2009mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.47), radiation dose (RA: 7269\u2009\u00b1\u200911288 vs. IVL: 5010\u2009\u00b1\u20094140\u2009cGy\u2009cm<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.68), and procedure time (RA: 79.5\u2009\u00b1\u200934.5 vs. IVL: 66.0\u2009\u00b1\u200919.4\u2009min; <jats:italic>p<\/jats:italic>\u2009=\u20090.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IVL is non\u2010inferior regarding MSA and results in a similar stent expansion in a random comparison with RA. Procedure time, contrast volume, and dose\u2010area product do not differ significantly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30815","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:10:15Z","timestamp":1693908615000},"page":"823-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Coronary intravascular lithotripsy and rotational atherectomy for severely calcified stenosis: Results from the ROTA.shock trial"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-3663","authenticated-orcid":false,"given":"F.","family":"Blachutzik","sequence":"first","affiliation":[{"name":"Medizinische Klinik 1 Justus Liebig Universit\u00e4t Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meier","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Justus Liebig Universit\u00e4t Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Weissner","sequence":"additional","affiliation":[{"name":"Kerckhoff\u2010Klinik, Kardiologie Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schlattner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Justus Liebig Universit\u00e4t Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-6707","authenticated-orcid":false,"given":"T.","family":"Gori","sequence":"additional","affiliation":[{"name":"Kardiologie 1 Universit\u00e4tsmedizin Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Kardiologie 1 Universit\u00e4tsmedizin Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-908X","authenticated-orcid":false,"given":"L.","family":"Gaede","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-095X","authenticated-orcid":false,"given":"S.","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"M\u00f6llmann","sequence":"additional","affiliation":[{"name":"St. Johannes\u2010Hospital, Innere Medizin 1 Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Chitic","sequence":"additional","affiliation":[{"name":"St. Johannes\u2010Hospital, Innere Medizin 1 Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-9078","authenticated-orcid":false,"given":"A.","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 2 Universit\u00e4tsklinikum Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 2 Universit\u00e4tsklinikum Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Weferling","sequence":"additional","affiliation":[{"name":"Kerckhoff\u2010Klinik, Kardiologie Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pons\u2010K\u00fchnemann","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Justus Liebig University Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Justus Liebig Universit\u00e4t Giessen Giessen Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Rhine\u2010Main Partner Site  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3533","authenticated-orcid":false,"given":"N.","family":"Boeder","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Justus Liebig Universit\u00e4t Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bayer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Justus Liebig Universit\u00e4t Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Els\u00e4sser","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin \u2010 Kardiologie Universit\u00e4tsklinikum Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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