{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:08:54Z","timestamp":1782169734953,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence of clinical impact of PPM after TAVI is conflicting and might vary according to the type of valve implanted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the clinical impact of prosthesis\u2010patient mismatch (PPM) after transcatheter aortic valve implantation (TAVI) with balloon\u2010expandable (BEV) and self\u2010expandable valves (SEV) in patients with small annuli.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TAVI\u2010SMALL 2 enrolled 628 patients in an international retrospective registry, which included patients with severe aortic stenosis and small annuli (annular perimeter\u2009&lt;72\u2009mm or area\u2009&lt;400\u2009mm<jats:sup>2<\/jats:sup>) treated with transfemoral TAVI at 16 high\u2010volume centers between 2011 and 2020. Analyses were performed comparing patients with less than moderate (<jats:italic>n<\/jats:italic>\u2009=\u2009452), moderate (<jats:italic>n<\/jats:italic>\u2009=\u2009138), and severe PPM (<jats:italic>n<\/jats:italic>\u2009=\u200938). Primary endpoint was incidence of all\u2010cause mortality. Predictors of all\u2010cause mortality and PPM were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow\u2010up of 380 days (interquartile range: 210\u2013709 days), patients with severe PPM, but not moderate PPM, had an increased risk of all\u2010cause mortality when compared with less than moderate PPM (log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.046). Severe PPM predicted all\u2010cause mortality in patients with BEV (hazard ratio [HR]: 5.20, 95% confidence interval [CI]: 1.27\u201321.2) and intra\u2010annular valves (IAVs, HR: 4.23, 95% CI: 1.28\u201314.02), and it did so with borderline significance in the overall population (HR: 2.89, 95% CI: 0.95\u20138.79). Supra\u2010annular valve (SAV) implantation was the only predictor of severe PPM (odds ratio: 0.33, 95% CI: 0.13\u20130.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with small aortic annuli and severe PPM after TAVI have an increased risk of all\u2010cause mortality at early term follow\u2010up, especially after IAV or BEV implantation. TAVI with SAV protected from severe PPM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30818","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:53:50Z","timestamp":1693907630000},"page":"931-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prosthesis\u2010patient mismatch after transcatheter implantation of contemporary balloon\u2010expandable and self\u2010expandable valves in small aortic annuli"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-4760","authenticated-orcid":false,"given":"Pier Pasquale","family":"Leone","sequence":"first","affiliation":[{"name":"Division of Cardiology Montefiore Medical Center Bronx New York USA"},{"name":"Department of Biomedical Sciences Humanitas University Pieve Emanuele, Milan Italy"},{"name":"Cardio Center IRCCS Humanitas Research Hospital Rozzano, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Regazzoli","sequence":"additional","affiliation":[{"name":"Cardio Center IRCCS Humanitas Research Hospital Rozzano, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-7871","authenticated-orcid":false,"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical specialties, Radiological Sciences and Public Health Institute of Cardiology, ASST Spedali Civili, University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-8988","authenticated-orcid":false,"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Centro Alte Specialita\u0300 e Trapianti, A.O.U. Policlinico \u201cG. Rodolico\u2014San Marco\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-6878","authenticated-orcid":false,"given":"Rui","family":"Teles","sequence":"additional","affiliation":[{"name":"Hospital de Santa Cruz Centro Hospitalar de Lisboa Ocidental, Nova Medical School, CEDOC Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":false,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical specialties, Radiological Sciences and Public Health Institute of Cardiology, ASST Spedali Civili, University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-1153","authenticated-orcid":false,"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"HerzZentrum Hirslanden Zurich University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato, San Donato Milanese Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-4046","authenticated-orcid":false,"given":"Antonio","family":"Mangieri","sequence":"additional","affiliation":[{"name":"GVM Care and Research Maria Cecilia Hospital Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-9976","authenticated-orcid":false,"given":"Faraj","family":"Kargoli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Montefiore Medical Center Bronx New York 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Medicine, Division of Cardiology University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Maffeo","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Interventional Cardiology Unit, Fondazione Poliambulanza Istituto Ospedaliero Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-7478","authenticated-orcid":false,"given":"Won\u2010Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"Cardio\u2010Thoracic\u2010Vascular Department IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department 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