{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:51:28Z","timestamp":1769827888212,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with severe aortic stenosis (AS) and concomitant severe coronary artery disease (CAD), the relative merits of a combined percutaneous (transcatheter aortic valve implantation [TAVI] and percutaneous coronary intervention [PCI]] versus surgical approach (surgical aortic valve replacement [SAVR] and coronary artery bypass graft [CABG]) remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the utility of combined percutaneous versus surgical approaches in patients with severe AS and CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Readmission Database (NRD) (2015\u20132019) was queried to identify all cases of TAVI+PCI and SAVR+CABG. The adjusted odds ratios (aOR) of mortality, stroke, and its composite (major adverse cardiovascular events [MACE]) were calculated using a propensity\u2010score matched (PSM) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 89,314 (5358 TAVI+PCI, 83,956 SAVR+CABG) patients were included in the crude analysis. There was a gradual increase in the utilization of TAVI+PCI from 2016 to 2019 by 2%\u20134% per year. Using PSM, a subset of 11,361 (5358 TAVI+PCI, 6003 SAVR+CABG) patients with a balanced set of demographics and baseline comorbidities was selected. During index hospitalization, the adjusted odds of MACE (aOR 0.72, 95% confidence interval [CI] 0.62\u20130.83), and all\u2010cause mortality (aOR 0.68, 95% CI 0.57\u20130.81) were significantly lower in patients undergoing TAVI+PCI compared with SAVR+CABG. However, patients undergoing TAVI+PCI had a higher incidence of MACE (aOR 1.40, 95% CI 1.05\u20131.87), and mortality (aOR 1.75, 95% CI 1.22\u20132.50) at 30\u2010days. The risk of index\u2010admission (aOR 0.82, 95% CI 0.62\u20131.09) and 30\u2010day (aOR 0.88, 95% CI 0.51\u20131.51) stroke was similar between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In selected patients with severe AS and concomitant CAD, a combined percutaneous approach (TAVR+PCI) compared with SAVR+CABG may confer a lower risk of MACE and mortality during index admission but a higher incidence of 30\u2010day complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30832","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:58:15Z","timestamp":1694523495000},"page":"946-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trends and outcomes of combined percutaneous (TAVI+PCI) and surgical approach (SAVR+CABG) for patients with aortic valve and coronary artery disease: A National Readmission Database (NRD) analysis"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-0309","authenticated-orcid":false,"given":"Waqas","family":"Ullah","sequence":"first","affiliation":[{"name":"Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-5060","authenticated-orcid":false,"given":"Deepika","family":"Sarvepalli","sequence":"additional","affiliation":[{"name":"Guntur Medical College Guntur Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-7875","authenticated-orcid":false,"given":"Arnav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart &amp; Vascular Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2754-9397","authenticated-orcid":false,"given":"Salman","family":"Zahid","sequence":"additional","affiliation":[{"name":"Rochester General Hospital Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-0906","authenticated-orcid":false,"given":"Sameer","family":"Saleem","sequence":"additional","affiliation":[{"name":"University of Kentucky Bowling Green Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza Z. U.","family":"Muhammadzai","sequence":"additional","affiliation":[{"name":"Abington Hospital Abington Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furqan","family":"Khattak","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-2849","authenticated-orcid":false,"given":"Peter C.","family":"Block","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wissam A.","family":"Jaber","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi H.","family":"Shishehbor","sequence":"additional","affiliation":[{"name":"University Hospitals Harrington Heart and Vascular Institute Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-1732","authenticated-orcid":false,"given":"Steven J.","family":"Filby","sequence":"additional","affiliation":[{"name":"University Hospitals Harrington Heart and Vascular Institute Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan","family":"Devireddy","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia 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