{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:29:18Z","timestamp":1747981758912,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the current study was to analyze the clinical and procedural predictors of thrombocytopenia and the relationship between the decrease in platelet count (DPC) and change in vWF function (\u0394vWF) after transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>TAVR often causes temporary thrombocytopenia. At the same time, TAVR leads to a restoration of von Willebrand factor (vWF) function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and forty\u2010one patients with severe aortic stenosis undergoing TAVR were included in the study. Platelet count and vWF function (vWF:Ac\/Ag ratio) were assessed at baseline and 6\u2009h after TAVR. Thrombocytopenia was defined as platelet count &lt;150\/nL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median platelet count at baseline was 214\/nL (interquartile range [IQR]: 176\u2013261) and decreased significantly to 184\/nL (IQR: 145\u2013222) 6\u2009h after TAVR. The number of patients with thrombocytopenia increased from 12.8% at baseline to 29.1% after 6\u2009h. DPC 6\u2009h after TAVR showed a significant correlation with \u0394vWF (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212 0.254, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Patients with DPC\u2009&gt;\u200920% had significantly higher \u0394vWF (10.9% vs. 6.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.021). Obese patients showed a significantly lower DPC (11.8% vs. 19.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). In multivariate analysis, \u0394vWF 6\u2009h after TAVR was the only significant predictor for DPC\u2009&gt;\u200920% (<jats:italic>p<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The restoration of vWF after TAVR is a significant predictor for DPC after TAVR. An increased platelet consumption due to vWF restoration could play a key role in the development of thrombocytopenia after TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30841","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T07:48:05Z","timestamp":1695196085000},"page":"1376-1385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Restoration of von Willebrand factor after transcatheter aortic valve replacement\u2014A possible cause for posttranscatheter aortic valve replacement thrombocytopenia?"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-8396","authenticated-orcid":false,"given":"Nastasia","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University Medical Center Regensburg 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