{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:24:44Z","timestamp":1761110684123,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the prognostic significance of the SYNTAX score (SS) and SYNTAX score II (SS\u2010II) in a contemporary real\u2010world cohort of myocardial infarction (MI) patients treated with percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of SS\u00a0and SS\u2010II in the prognostic stratification of patients presenting with MI and undergoing PCI has been poorly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included MI patients treated with PCI from January 2015 to April 2020 at the University Hospital of Salerno. Patients were divided into tertiles according to the baseline SS and SS\u2010II values. The primary outcome measure was all\u2010cause mortality at long\u2010term follow\u2010up; secondary outcome measures were cardiovascular (CV) death and MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 915 patients were included in this study. Mean SS and SS\u2010II were 16.1\u2009\u00b1\u200910.0 and 31.6\u2009\u00b1\u200911.5, respectively. At propensity weighting adjusted Cox regression analysis, both SS (hazard ratio [HR]: 1.02; 95% confidence interval [CI]: 1.02\u22121.06; <jats:italic>p<\/jats:italic>\u2009=\u20090.017) and SS\u2010II (HR: 1.08; 95%\u00a0CI: 1.07\u22121.10; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly associated with the risk of all\u2010cause mortality at long\u2010term follow\u2010up; both SS (HR 1.04; CI 1.01\u22121.06; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and SS\u2010II (HR 1.08; CI 1.06\u22121.10; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly associated with the risk of CV death, but only SS\u2010II showed a significant association with the risk of recurrent MI (HR 1.03; CI 1.01\u22121.05; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At 5 years, SS\u2010II showed a significantly higher discriminative ability for all\u2010cause mortality than SS (area under the curve: 0.82 vs. 0.64; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). SS\u2010II was able to reclassify the risk of long\u2010term mortality beyond the SS (net reclassification index 0.88; 95%\u00a0CI: 0.38\u22121.54; <jats:italic>p<\/jats:italic>\u2009=\u20090.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a real\u2010world cohort of MI patients treated with PCI, SS\u2010II was a stronger prognostic predictor of long\u2010term mortality than SS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30842","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:19:33Z","timestamp":1694596773000},"page":"779-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic significance of the SYNTAX score and SYNTAX score II in patients with myocardial infarction treated with percutaneous coronary intervention"],"prefix":"10.1002","volume":"102","author":[{"given":"Marco","family":"Di Maio","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-639X","authenticated-orcid":false,"given":"Luca","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Silverio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Bellino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Paolo","family":"Cancro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Division of Cardiology, AOU \u201cPoliclinico G. Martino\u201d University of Messina Messina Italy"},{"name":"Division of Cardiology IRCCS Hospital Galeazzi\u2010Sant'Ambrogio Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-6555","authenticated-orcid":false,"given":"Francesca Maria","family":"Di Muro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Clinica Medica, Structural Interventional Cardiology Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giovanna","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Vecchione","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) Italy"},{"name":"Vascular Pathophysiology Unit IRCCS Neuromed Pozzilli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Galasso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno Baronissi (Salerno) 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