{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:24Z","timestamp":1791410904679,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence and predictors of 30\u2010day stroke after transcatheter aortic valve replacement (TAVR) were derived from early studies investigating first\u2010generation devices. The incidence of 6\u2010month stroke and its related predictors are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the incidence and to identify procedural and patient\u2010related predictors of 30\u2010day and 6\u2010month stroke after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 2753 consecutive patients with severe aortic stenosis undergoing TAVR were obtained from the OBSERVANT\u2010II study, an observational, prospective, multicenter cohort study. The study endpoints were symptomatic 30\u2010day and 6\u2010month stroke after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The occurrence of a 30\u2010day and 6\u2010month stroke was low (1.3% and 2.4%, respectively) but with significant impact on survival. Aortic valve predilatation (odds ratio [OR]: 2.28, 95% confidence interval [CI]: 1.12\u20134.65, <jats:italic>p<\/jats:italic>\u2009=\u20090.023), diabetes (OR: 3.10, 95% CI: 1.56\u20136.18, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and left ventricle ejection fraction\u2009&lt;\u200950% (OR: 2.15, 95% CI: 1.04\u20134.47, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) were independent predictors of 30\u2010day stroke, whereas diabetes (sub\u2010distribution hazard ratio [SHR]: 2.07, 95% CI: 1.25\u20133.42, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), pre\u2010existing neurological dysfunction (SHR: 3.92, 95% CI: 1.54\u201310, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), bicuspid valve (SHR: 4.75, 95% CI: 1.44\u201315.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.011), and critical status (SHR: 3.05, 95% CI: 1.21\u20137.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) were predictive of 6\u2010month stroke. Conversely, antiplatelet therapy and anticoagulation were protective factors at both 30 days and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stroke after TAVR was rare. Predilatation was the only procedural factor predictive of 30\u2010day stroke, whereas the remaining were patient\u2010related risk factors, suggesting appropriate risk stratification preoperatively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30848","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:29:42Z","timestamp":1696534182000},"page":"1122-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence and predictors of 30\u2010day and 6\u2010month stroke after TAVR: Insights from the multicenter OBSERVANT II study"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-5289","authenticated-orcid":false,"given":"Riccardo","family":"Gorla","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology IRCCS Policlinico San Donato, San Donato Milanese Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-8290","authenticated-orcid":false,"given":"Lorenzo","family":"Tua","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology IRCCS Policlinico San Donato, San Donato Milanese Milan Italy"},{"name":"Department of Cardiology, IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"D'Errigo","sequence":"additional","affiliation":[{"name":"National Center for Global Health Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, A.O.U. 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Rodolico\u2014San Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-8186","authenticated-orcid":false,"given":"Fausto","family":"Biancari","sequence":"additional","affiliation":[{"name":"Department of Medicine, South Karelia Central Hospital University of Helsinki Lappeenranta Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-2917","authenticated-orcid":false,"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Badoni","sequence":"additional","affiliation":[{"name":"National Center for Global Health Istituto Superiore di Sanit\u00e0 Rome 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