{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:11:16Z","timestamp":1740103876546,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most randomized studies testing the effectiveness of IVBT were limited to vessels less than 4 mm diameter. In fact, it is now common to treat vessels larger than 4 mm. Accordingly, the authors instituted a prescription dose increase to 34 Gy at 2 mm from source center for vessels greater than 4.0 mm. The increase in prescription dose to 34 Gy at 2 mm from center is substantial, being 50% higher than the conventional maximum of 23 Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To take a close look at group of patients treated to 34 Gy, and for whom follow\u2010up angiograms are available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients treated for ISR with a prescription dose of 34 Gy and for whom follow\u2010up angiograms were available were studied. Beta\u2010radiation brachytherapy was performed with a Novoste Beta\u2010Cath System using a strontium\u201090 (beta) source (Best Vascular, Springfield, VA). Source lengths of 40 or 60 mm were used. A dose of 34 Gy was prescribed at 2 mm from the source center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were re\u2010catheterized from 2 to 21 months (median: 16 months) following IVBT, all for symptoms suggested of restenosis. All patients had some degree of ISR of the target vessel, but no IVBT\u2010treated vascular segment showed angiographic signs of degeneration, dissection or aneurysm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The authors' clinical impression, along with detailed review of the 10 cases, suggest that using a 34 Gy prescription dose at 2 mm from source center does not result in increased toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30852","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T09:07:33Z","timestamp":1697706453000},"page":"1034-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased prescription dose for large vessel intravascular 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Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-0360","authenticated-orcid":false,"given":"Lorenzo","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Sandison","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Washington Seattle 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