{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:21:12Z","timestamp":1783470072786,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) is as an alternative treatment to surgical AVR, but the long\u2010term outcomes of TAVR remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to analyze long\u2010term outcomes following TAVR using meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed with MEDLINE, EMBASE, Cochrane Library, Web of Science, and Google Scholar through November 2022; studies reporting clinical outcomes of TAVR with follow\u2010up periods of \u22658 years were included. The outcomes of interest were overall survival and\/or freedom from structural valve deterioration (SVD). Surgical risk was assessed with the Society of Thoracic Surgeons (STS) predicted risk of mortality (PROM) score. A subgroup analysis was conducted for intermediate\u2010\/high\u2010surgical risk patients only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies including 5458 patients were identified and analyzed. The mean age was 82.0\u2009\u00b1\u20096.5 years, and mean STS PROM score ranged from 2.9\u00a0to 10.6%. Survival rate at 5 and 10 years was 47.7% \u00b1 1.4% and 12.1\u2009\u00b1\u20092.0%. Five studies including 1509 patients were analyzed for SVD. Freedom from SVD at 5 and 8 years was 95.5\u2009\u00b1\u20090.7% and 85.1\u2009\u00b1\u20093.1%. Similar results for survival and SVD were noted in the subgroup analysis of intermediate\u2010\/high\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Following TAVR, approximately 88% of patients died within 10 years, whereas 85% were free from SVD at 8 years. These date suggest that baseline patient demographic have the greatest impact on survival, and SVD does not seem to have a prognostic impact in this population. Further investigations on longer\u2010term outcomes of younger and lower\u2010risk patients are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30854","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T18:26:41Z","timestamp":1698431201000},"page":"1291-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term outcomes after transcatheter aortic valve replacement: Meta\u2010analysis of Kaplan\u2212Meier\u2010derived data"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-5036","authenticated-orcid":false,"given":"Junichi","family":"Shimamura","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Cardiothoracic Surgery Emory University School of Medicine Atlanta Georgia 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