{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:49:47Z","timestamp":1772894987921,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the current study sought to investigate the angiographic patterns of restenosis after drug\u2010coated balloon (DCB) angioplasty for femoropopliteal (FP) lesions and which repeat endovascular therapy (EVT) for DCB restenosis would provide more freedom from recurrent restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective multicenter study included 119 limbs (chronic limb\u2010threatening ischemia [CLTI]: 55%, lesion length: 136.9\u2009\u00b1\u200989.6\u2009mm, chronic total occlusion: 25%) of 95 patients (diabetes mellitus: 70%, hemodialysis: 56%) who were diagnosed with DCB restenosis between January 2018 and December 2019. The cases were classified into three groups based on angiographic patterns of restenosis: Class I: focal lesions \u226450\u2009mm, Class II: diffuse lesions &gt;50\u2009mm, and Class III: totally occluded lesions. The DCB restenosis patterns and frequency and predictors of recurrent restenosis after repeated\u00a0EVT (re\u2010EVT) were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up duration was 29.8\u2009\u00b1\u20099.5 months. Groups I, II, and III comprised of 30 (25.2%), 55 (46.2%), and 34 (29.0%) cases, respectively. The overall rate of 1\u2010year freedom from recurrent restenosis was 58.2%. One\u2010year rate of freedom from recurrent restenosis after repeat DCB was not statistically different from that after scaffolding (71.1% vs. 74.6%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.911); however, it was significantly better than that after noncoated balloon angioplasty (repeat DCB vs. noncoated balloon angioplasty: 71.1% vs. 25.7%, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analysis demonstrated that CLTI (hazard ratio [HR]: 5.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and re\u2010EVT with noncoated balloon (HR: 3.16, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly associated with recurrent restenosis; however, Class III pattern of DCB restenosis was not associated with recurrent restenosis (HR: 1.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.918).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study revealed the angiographic patterns of restenosis after DCB therapy for FP lesions and the 1\u2010year rate of recurrent restenosis after repeat revascularization. Repeat DCB therapy demonstrated acceptable 1\u2010year recurrent restenosis rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30856","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:55:01Z","timestamp":1697705701000},"page":"1114-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Angiographic patterns of restenosis after drug\u2010coated balloon angioplasty for femoropopliteal lesions and 1\u2010year prognosis after repeat endovascular therapy"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-4130","authenticated-orcid":false,"given":"Naoko","family":"Higashino","sequence":"first","affiliation":[{"name":"Kansai Rosai Hospital Cardiovascular Center Amagasaki Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-7304","authenticated-orcid":false,"given":"Osamu","family":"Iida","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-0817","authenticated-orcid":false,"given":"Takayuki","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Kansai Rosai Hospital Cardiovascular Center Amagasaki Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Hata","sequence":"additional","affiliation":[{"name":"Kansai Rosai Hospital Cardiovascular Center Amagasaki Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-5227","authenticated-orcid":false,"given":"Taku","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-2892","authenticated-orcid":false,"given":"Tomofumi","family":"Tsukizawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kishiwada Tokushukai Hospital Kishiwada Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Nishian","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morinomiya Hospital Morinomiya Osaka 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and Cardiovascular 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