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Although the current generation DES offer excellent results, as we embark more complex lesions such as calcified lesion and chronic total occlusion, restenosis and stent thrombosis are higher and tend to increase within the years. There is increasing desire to leave nothing behind to abolish the risk of restenosis and stent thrombosis and hence the absorbable scaffolds were introduced, but with disappointing results. In addition, they take several years to be absorbed. Drug coated balloons offer an alternative to stents with no permanent implant of metal or polymer. They are already in use in in Europe and Asia and they have been approved for the first time in the United States for clinical trials specifically for restenotic lesions. There is emerging data in de novo lesions which have shown that DCB are noninferior and in some studies maybe even superior to current generation DES especially in small vessels. In this article, we provide a comprehensive review of the literature on this expanding technology focussing on the evidence in both re\u2010stenotic and de novo lesions.<\/jats:p>","DOI":"10.1002\/ccd.30891","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:49:10Z","timestamp":1698058150000},"page":"1069-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The evolution and revolution of drug coated balloons in coronary angioplasty: An up\u2010to\u2010date review of literature data"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-7810","authenticated-orcid":false,"given":"Bernardo","family":"Cortese","sequence":"first","affiliation":[{"name":"Fondazione Ricerca e Innovazione Cardiovascolare Milano Italy"},{"name":"DCB Academy Milano Italy"},{"name":"Cardioparc Lyon 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