{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:09:51Z","timestamp":1740103791275,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The European Society of Cardiology (ESC) 0\/1\u2010h Algorithm with high\u2010sensitivity cardiac troponin T (hs\u2010cTnT) has shown promising results in risk stratification and management of patients with coronary artery disease (CAD). However, its outcomes and clinical implications in the context of developing countries remain understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study aimed to evaluate the outcomes and clinical significance of the ESC 0\/1\u2010h Algorithm in a developing country setting. A total of 3534 patients with CAD were enrolled, with 1125 in the Rule\u2010Out group and 2409 in the Rule\u2010In group. Baseline characteristics, performance metrics, primary and secondary outcomes, and predictors of Rule\u2010In and Rule\u2010Out groups were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study enrolled 3534 patients with CAD, with 1125 in the Rule\u2010Out group and 2409 in the Rule\u2010In group. The 0\/1\u2010h Algorithm with hs\u2010cTnT demonstrated improved performance compared to Troponin T at Presentation. It exhibited higher sensitivity, specificity, negative predictive value, positive predictive value, and area under the curve (AUC) for risk stratification in patients with CAD. Significant differences were observed in baseline characteristics between the Rule\u2010Out and Rule\u2010In groups, including age, gender, and comorbidities. The Rule\u2010In group had a higher incidence of adverse cardiac events and underwent more invasive procedures compared to the Rule\u2010Out group. Age, gender, hypertension, diabetes, and smoking were identified as significant predictors of Rule\u2010In and Rule\u2010Out. These findings highlight the clinical significance of implementing the 0\/1\u2010h Algorithm in the management of patients with CAD in a developing country setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The algorithm's performance, along with its ability to identify high\u2010risk patients and predict outcomes, highlights its potential to enhance patient care and outcomes in resource\u2010limited settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30905","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T09:19:48Z","timestamp":1699175988000},"page":"1155-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of European Society of Cardiology 0\/1\u2010h algorithm with high\u2010sensitivity cardiac troponin T among patients with coronary artery disease"],"prefix":"10.1002","volume":"102","author":[{"given":"Muhammad Omer Rehman","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Armed Forces Institute of Cardiology Rawalpindi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aatika","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guy's and St. Thomas' NHS Trust London Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Abdullah Amir","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Ayub","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafia","family":"Zubair","sequence":"additional","affiliation":[{"name":"Department of Medicine Gujranwala Medical College Gujranwala Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Armed Forces Institute of Cardiology Rawalpindi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-4187","authenticated-orcid":false,"given":"Jahanzeb","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cardiovascular Analytics Group Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waheed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Abbas Institute of Medical Sciences Muzaffrabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Awais","sequence":"additional","affiliation":[{"name":"Department of Cardiology Islamic International Medical College Rawalpindi 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