{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T12:42:56Z","timestamp":1772368976170,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atherectomy use in treatment of femoropopliteal disease has significantly increased despite scant evidence of benefit to long\u2010term clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated the clinical benefits of atherectomy over standard treatment for femoropopliteal interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the Society of Vascular Surgery's Vascular Quality Initiative (VQI) registry, we identified patients who underwent isolated femoropopliteal interventions for occlusive disease. We compared 13,423 patients treated with atherectomy with 47,371 receiving standard treatment; both groups were allowed definitive treatment with a drug\u2010coated balloon or stenting. The primary endpoint was major adverse limb events (MALEs), which is a composite of target vessel re\u2010occlusion, ipsilateral major amputation, and target vessel revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 69\u2009\u00b1\u200911 years, and patients were followed for a median of 30 months. Overall rates of complications were slightly higher in the atherectomy group than the standard treatment group (6.2% vs. 5.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In multivariable analysis, after adjusting for demographic and clinical covariates, atherectomy use was associated with a 13% reduction in risk of MALEs (adjusted odds ratio [aOR]: 0.87; 95% confidence interval [CI]: 0.77\u20130.98). Rates of major and minor amputations were significantly lower in the atherectomy group (3.2% vs. 4.6% and 3.3% vs. 4.3%, respectively, both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), primarily driven by a significantly decreased risk of major amputations (aOR 0.69; 95% CI: 0.52\u20130.91). There were no differences in 30\u2010day mortality, primary patency, and target vessel revascularization between the atherectomy and standard treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adults undergoing femoropopliteal interventions, the use of atherectomy was associated with a reduction in MALEs compared with standard treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30912","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:34:50Z","timestamp":1700602490000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of atherectomy on major adverse limb events for femoropopliteal interventions: Vascular Quality Initiative registry"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-1151","authenticated-orcid":false,"given":"Valery S.","family":"Effoe","sequence":"first","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8141-8852","authenticated-orcid":false,"given":"Mark W.","family":"Mewissen","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-0879","authenticated-orcid":false,"given":"Tanvir K.","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-0171","authenticated-orcid":false,"given":"Jayant","family":"Khitha","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-4884","authenticated-orcid":false,"given":"Louie","family":"Kostopoulos","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-7051","authenticated-orcid":false,"given":"Khawaja A.","family":"Ammar","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-0315","authenticated-orcid":false,"given":"Tonga K.","family":"Nfor","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular and Thoracic Services, Aurora Sinai\/Aurora St. Luke's Medical Centers Advocate Aurora Health Milwaukee Wisconsin USA"},{"name":"Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.03.864"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.12.059"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.01.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.01.060"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.048"},{"issue":"9","key":"e_1_2_10_7_1","article-title":"Atherectomy for peripheral arterial disease","volume":"9","author":"Wardle BG","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004848"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70267-9"},{"key":"e_1_2_10_9_2","unstructured":"discussion268\u2010269."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.05.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025329"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870230802"},{"issue":"8","key":"e_1_2_10_13_1","first-page":"355","article-title":"The COMPLIANCE 360\u00b0 Trial: a randomized, prospective, multicenter, pilot study comparing acute and long\u2010term results of orbital atherectomy to balloon angioplasty for calcified femoropopliteal disease","volume":"26","author":"Dattilo R","year":"2014","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27635"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.03.016"},{"key":"e_1_2_10_18_1","unstructured":"Society for Vascular Surgery. Vascular Quality Initiative website. Accessed April 27 2022.https:\/\/vascularqualityinitiative.org\/"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012081"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2022.11.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1538574418772459"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.05.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.01.066"},{"issue":"5","key":"e_1_2_10_24_1","first-page":"655","article-title":"Atherectomy of the femoropopliteal artery: a systematic review and meta\u2010analysis of randomized controlled trials","volume":"55","author":"Diamantopoulos A","year":"2014","journal-title":"J Cardiovasc Surg"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1583\/13-4308MR.1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1583\/09-2826.1"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:00:17Z","timestamp":1741766417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/ccd.30912"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30912","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}