{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:16:25Z","timestamp":1770729385236,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary embolism (PE)\u00a0is a common complication among patients with cancer and is a significant contributor to morbidity and mortality. Catheter\u2010based therapies (CBT),\u00a0including catheter\u2010directed thrombolysis (CDT)\u00a0and mechanical thrombectomy, have been developed and are used in patients with intermediate or high\u2010risk PE. However, there is a paucity of data on outcomes in patients with cancer as most clinical studies exclude this group of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To characterize outcomes of patients with cancer admitted with intermediate or high\u2010risk PE treated with CBT compared with no CBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with an admission diagnosis of intermediate or high\u2010risk PE and a history of cancer from October 2015 to December 2018 were identified using the National Inpatient Sample. Outcomes of interest were in\u2010hospital death or cardiac arrest (CA)\u00a0and major bleeding. Inverse probability treatment weighting (IPTW)\u00a0was utilized to compare outcomes between patients treated with and without CBT. Variables that remained unbalanced after IPTW were adjusted using multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2084 unweighted admissions (10,420 weighted) for intermediate or high\u2010risk PE and cancer were included, of which 136 (6.5%) were treated with CBT. After IPTW, CBT was associated with lower death or CA (aOR 0.54, 95% CI 0.46\u20130.64) but higher major bleeding (aOR\u00a01.41, 95% CI 1.21\u20131.65). After stratifying by PE risk type, patients treated with CBT had lower risk of death or CA in both intermediate (aOR\u00a00.52, 95% CI 0.36\u20130.75) and high\u2010risk PE (aOR\u00a00.48, 95% CI 0.33\u20130.53). However, patients with CBT were associated with increased risk of major bleeding in intermediate\u2010risk PE (aOR\u00a02.12, 95% CI 1.67\u20132.69) but not in those with high\u2010risk PE (aOR\u00a00.84, 95% CI 0.66\u20131.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with cancer hospitalized with intermediate or high\u2010risk PE, treatment with CBT was associated with lower risk of in\u2010hospital death or CA but higher risk of bleeding. Prospective studies and inclusion of patients with cancer in randomized trials are warranted to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30917","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T01:07:33Z","timestamp":1700874453000},"page":"348-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Catheter\u2010based therapy for intermediate or high\u2010risk pulmonary embolism is associated with lower in\u2010hospital mortality in patients with cancer: Insights from the National Inpatient Sample"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-6380","authenticated-orcid":false,"given":"Orly","family":"Leiva","sequence":"first","affiliation":[{"name":"Department of Medicine,\u00a0Division of Cardiology New York University Grossman School of Medicine New York New York 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikramjit","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonology and Critical Care New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonology and Critical Care New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Medicine,\u00a0Division of Cardiology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Alviar","sequence":"additional","affiliation":[{"name":"Department of Medicine,\u00a0Division 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