{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:40:18Z","timestamp":1741768818996,"version":"3.38.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The ridaforolimus\u2010eluting stent (RES) system uses a novel cobalt alloy\u2010based coronary stent with a durable elastomeric polymer eluting ridaforolimus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of study<\/jats:title><jats:p>To assess the safety and efficacy of small diameter (2.25\u2009mm) RES (EluNIR) in small coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicenter, single\u2010arm, open\u2010label clinical trial. Clinical follow\u2010up was performed at 30 days, 6 months, and 1 year after the procedure. Target lesions were located in native coronary arteries or bypass graft conduits, with visually estimated diameter of \u22652.25\u2009mm to \u22642.5\u2009mm. The primary endpoint was combined device success, defined as final in\u2010stent residual diameter stenosis &lt;30%, without 30\u2010day major adverse cardiovascular events (MACE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 81 patients were enrolled in the study. Twenty\u2010three patients (28%) had acute coronary syndrome (ACS) at presentation and 37 (46%) had prior myocardial infarction (MI). Most of the target lesions were located in the circumflex coronary artery (44%) and were classified as B2\/C grade according to the American Heart Association\/American College of Cardiology\u00a0classification. The final mean minimal lumen diameter, mean reference vessel diameter, and mean residual percent diameter stenosis were 2.0\u2009\u00b1\u20090.2\u2009mm, 2.3\u2009\u00b1\u20090.1\u2009mm, and 14\u2009+\u20096.6%, respectively. The primary endpoint of device success without 30\u2010day MACE was achieved in 98.8% of the patients. Target lesion failure (TLF) at 6 months was 1.2%. Thirty\u2010day and 1\u2010year MACE rates were 1.2% and 2.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The EluNIR 2.25\u2009mm stent shows excellent results in small coronary artery disease and adds another tool in the treatment of this complex lesion type.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30924","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:26:58Z","timestamp":1702621618000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Percutaneous coronary intervention with ridaforolimus eluting\u2010stents in small vessel coronary artery disease"],"prefix":"10.1002","volume":"103","author":[{"given":"Ziad","family":"Arow","sequence":"first","affiliation":[{"name":"Cardiology Department Meir Medical Center Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv 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