{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:41:51Z","timestamp":1772131311927,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Among\u00a0patients undergoing percutaneous coronary intervention (PCI), in\u2010stent restenosis (ISR) is related with a worse prognosis, while higher body mass index (BMI) values are associated with better outcomes. It is unclear whether the prognostic impact of ISR varies in function of BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing PCI at a large center from 2012 to 2019 not presenting with an acute myocardial infarction (MI) were included. Subjects with BMI\u2009&lt;\u200918.5\u2009kg\/m<jats:sup>2<\/jats:sup> or treated with bare metal stents were excluded. Patients were stratified according to type of lesion treated (ISR vs. no\u2010ISR) and into four\u00a0BMI categories: normal weight (BMI 18.5\u201325\u2009kg\/m<jats:sup>2<\/jats:sup>), overweight (25.0\u201329.9\u2009kg\/m<jats:sup>2<\/jats:sup>), class I obesity (30.0\u201334.9\u2009kg\/m<jats:sup>2<\/jats:sup>), class II\u2013III obesity (\u226535.0\u2009kg\/m<jats:sup>2<\/jats:sup>). The primary outcome was major adverse cardiovascular events (MACE), a composite of all\u2010cause death, MI, and target vessel revascularization (TVR) at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 16,234 patients, 3694 (23%) underwent PCI for ISR. ISR as compared to no\u2010ISR was associated with a consistent increased risk of MACE within the normal weight (18.8% vs. 7.8%, adj.\u00a0hazard ratio\u00a0(HR):\u00a01.99, 95%\u00a0confidence interval\u00a0[CI]:\u00a01.51\u20132.64), overweight (19.1% vs. 6.4%, adj. HR:\u00a02.35, 95% CI: 1.91\u20132.88), class I obesity (18.3% vs. 6.8%, adj. HR: 1.95, 95% CI: 1.47\u20132.57), and class II\u2013III obesity (16.4% vs. 7.4%, adj. HR: 1.61, 95% CI: 1.09\u20132.37) groups (interaction <jats:italic>p<\/jats:italic>\u2010value: 0.192). The ISR\u2010related risks were mostly driven by an excess of TVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 1 year, ISR was associated with an increased risk of MACE irrespective of BMI, mostly due to an excess of TVR after ISR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30939","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T07:23:36Z","timestamp":1704353016000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic impact of in\u2010stent restenosis in normal weight, overweight, and obese patients undergoing percutaneous coronary intervention"],"prefix":"10.1002","volume":"103","author":[{"given":"Davis","family":"Jones","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"},{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-6577","authenticated-orcid":false,"given":"Alessandro","family":"Spirito","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9409","authenticated-orcid":false,"given":"Samantha","family":"Sartori","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Vogel","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison","family":"Edens","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Kamaleldin","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunna","family":"Pileggi","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"},{"name":"Department of Cardiopneumonology Heart Institute of the University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Baber","sequence":"additional","affiliation":[{"name":"Department of Cardiology The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-8049","authenticated-orcid":false,"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samin K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-3307","authenticated-orcid":false,"given":"Annapoorna","family":"Kini","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai,\u00a0Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. 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