{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:56:33Z","timestamp":1788389793099,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iliofemoral deep vein thrombosis (IFDVT) causes severe symptoms and affect the quality of life to a great extent. Endovascular thrombectomy and stent implantation have been a feasible strategie to alleviate the signs and symptoms of IFDVT. However, venous in\u2010stent restenosis (ISR) has become an emerging non\u2010negligible problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To evaluate the histological characteristics of venous ISR, neointima of arterial and venous ISR patients were collected and examed. To explore the effect of drug\u2010coated balloon (DCB) on venous ISR lesions, we conducted a single\u2010center retrospective case series study involving IFDVT patients with ISR after venous stenting who were treated with paclitaxel\u2010coated balloon dilatation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a collagen\u2010rich matrix but not elastin, as well as fewer cells and less neovascularization in venous intimal hyperplasia compared with neointima in arteries. Thirteen IFDVT patients were involved in the study, with average preoperative stenosis degree of 87.69%\u2009\u00b1\u200913.48%. After intervention, the stenosis degree was significantly reduced to 14.6%\u2009\u00b1\u200914.36% immediately (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and to 16.54%\u2009\u00b1\u200915.73% during follow\u2010up (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). During follow\u2010up, the VEINES\u2010QOL scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), VEINES\u2010Sym scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and Villalta scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) of patients was improved significantly compared with those before intervention. No major adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of DCB may have a positive effect in the treatment of venous ISR by targeting intimal hyperplasia. Moreover, the application of DCB dilatation in IFDVT stenting patients with ISR is deemed safe and effective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30975","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T10:32:52Z","timestamp":1708597972000},"page":"752-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Drug\u2010coated balloon therapy for in\u2010stent restenosis in patients with iliofemoral deep vein thrombosis: A single\u2010arm observational study"],"prefix":"10.1002","volume":"103","author":[{"given":"Jiahao","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongji","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China"},{"name":"Shanghai Key Laboratory of Tissue Engineering Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of 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