{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:55:07Z","timestamp":1758056107327,"version":"3.44.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nicorandil is widely used as a vasodilator for the physiological assessment of coronary arteries because of its usefulness and safety; however, there are no data on its use in peripheral arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To identify the utility of nicorandil and its appropriate dose for the physiological assessment on the femoropopliteal artery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled patients from three institutes in which physiological assessment was carried out with various doses of nicorandil before treatment. Twenty\u2010four femoropopliteal artery stenotic lesions from 22 patients were included. The nicorandil doses used were 2, 4, and 6\u2009mg. Twenty\u2010two lesions were also assessed using 30\u2009mg of papaverine. The pressure gradient (PG) and peripheral fractional flow reserve (pFFR) were calculated based on the mean and systolic pressure levels. We examined the correlation of each parameter with the peak systolic velocity ratio (PSVR) based on the duplex ultrasound images using Spearman's rank correlation coefficient. Systemic blood pressure was assessed for safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The correlations were higher for mean pressure\u2010based parameters than for systolic pressure\u2010based parameters. As the nicorandil dose increased, the correlations among PG, pFFR, and PSVR also increased (mean pressure\u2010based PG: 2\u2009mg, <jats:italic>r\u2009<\/jats:italic>=\u20090.360; 4\u2009mg, <jats:italic>r\u2009<\/jats:italic>=\u20090.498; 6\u2009mg, <jats:italic>r\u2009<\/jats:italic>=\u20090.694, mean pressure\u2010based pFFR: 2\u2009mg, <jats:italic>r\u2009<\/jats:italic>=\u2009\u22120.479; 4\u2009mg, <jats:italic>r\u2009<\/jats:italic>=\u2009\u22120.469; 6\u2009mg, <jats:italic>r\u2009<\/jats:italic>=\u2009\u22120.641). The blood pressure after the administration of 6\u2009mg of nicorandil was low, and the median systemic mean pressure was 65\u2009mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 4\u2009mg dose of nicorandil is effective and safe for the mean pressure\u2010based physiological assessment of lesions in the femoropopliteal artery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30976","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T06:19:33Z","timestamp":1708064373000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility and optimal dose of nicorandil for physiological assessment of the femoropopliteal artery"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-3794","authenticated-orcid":false,"given":"Naoki","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-9112","authenticated-orcid":false,"given":"Takenobu","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kyoto Katsura Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisako","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-3559","authenticated-orcid":false,"given":"Takanori","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kyoto Katsura Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiju","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuro","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"issue":"41","key":"e_1_2_9_2_1","first-page":"407","article-title":"ESC guidelines for the diagnosis and management of chronic coronary syndromes","volume":"2020","author":"Knuuti J","year":"2019","journal-title":"Eur Heart J"},{"issue":"40","key":"e_1_2_9_3_1","first-page":"87","article-title":"ESC\/EACTS guidelines on myocardial revascularization","volume":"2019","author":"Neumann FJ","year":"2018","journal-title":"Eur Heart 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