{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:40Z","timestamp":1791410920477,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) is a reasonable therapeutic approach among patients with symptomatic severe aortic stenosis irrespective of surgical risk. Data regarding sex\u2010specific differences in the outcomes with newer generation valves are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases were searched for studies assessing sex differences in the outcomes of patients undergoing TAVR with newer generation valves (SAPIEN 3 or Evolut). Random effects model was constructed for summary estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four observational studies with 4522 patients (44.8% women) were included in the meta\u2010analysis. Women were older and had a lower prevalence of coronary artery disease and mean EuroScore. Women had a higher incidence of short\u2010term mortality (up to 30 days) (risk ratio [RR]: 1.60, 95% confidence interval [CI]: 1.14\u20132.25), but no difference in 1\u2010year mortality (RR: 0.92, 95% CI: 0.72\u20131.17). There was no significant difference in the incidence of major bleeding (RR: 1.16, 95% CI: 0.86\u20131.57), permanent pacemaker (PPM) (RR: 0.80, 95% CI: 0.62\u20131.04), or disabling stroke (RR: 1.16, 95% CI: 0.54\u20132.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this meta\u2010analysis, we found that women undergoing TAVR with newer\u2010generation devices were older but had a lower prevalence of comorbidities. Women had a higher incidence of short\u2010term mortality but no difference in the 1\u2010year mortality, bleeding, PPM, or stroke compared with men. Future studies are required to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30985","type":"journal-article","created":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T04:19:56Z","timestamp":1710044396000},"page":"808-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex differences in the outcomes after transcatheter aortic valve replacement with newer generation devices: A meta\u2010analysis"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-0599","authenticated-orcid":false,"given":"Adham H.","family":"El Sherbini","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Health Sciences Queen's University Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Servito","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Manitoba 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