{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:54:04Z","timestamp":1782982444571,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous pulmonary valve implantation (PPVI) is a non\u2010surgical treatment for right ventricular outflow tract (RVOT) dysfunction. During PPVI, a stented valve, delivered via catheter, replaces the dysfunctional pulmonary valve. Stent oversizing allows valve anchoring within the RVOT, but overexpansion can intrude on the surrounding structures. Potentially dangerous outcomes include aortic valve insufficiency (AVI) from aortic root (AR) distortion and myocardial ischemia from coronary artery (CA) compression. Currently, risks are evaluated via balloon angioplasty\/sizing before stent deployment. Patient\u2010specific finite element (FE) analysis frameworks can improve pre\u2010procedural risk assessment, but current methods require hundreds of hours of high\u2010performance computation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We created a simplified method to simulate the procedure using patient\u2010specific FE models for accurate, efficient pre\u2010procedural PPVI (using balloon expandable valves) risk assessment. The methodology was tested by retrospectively evaluating the clinical outcome of 12 PPVI candidates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 12 patients (median age 14.5 years) with dysfunctional RVOT, 7 had native RVOT and 5 had RV\u2010PA conduits. Seven patients had undergone successful RVOT stent\/valve placement, three had significant AVI on balloon testing, one had left CA compression, and one had both AVI and left CA compression. A model\u2010calculated change of more than 20% in lumen diameter of the AR or coronary arteries correctly predicted aortic valve sufficiency and\/or CA compression in all the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Agreement between FE results and clinical outcomes is excellent. Additionally, these models run in 2\u20136\u2009min on a desktop computer, demonstrating potential use of FE analysis for pre\u2010procedural risk assessment of PPVI in a clinically relevant timeframe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31016","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:58:45Z","timestamp":1712732325000},"page":"924-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Finite element modeling with patient\u2010specific geometry to assess clinical risks of percutaneous pulmonary valve implantation"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-4384","authenticated-orcid":false,"given":"Carly L.","family":"Donahue","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Minnesota Twin Cities Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Westman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Minnesota Twin Cities Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany L.","family":"Faanes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics University of Minnesota Masonic Children's Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-568X","authenticated-orcid":false,"given":"Athar M.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Lillei Frank Abercombie Section of Pediatric Cardiology, Texas Children's Hospital and Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H.","family":"Barocas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Minnesota Twin Cities Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics University of Minnesota Masonic Children's Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023370"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X15666181224113855"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"KarlTR.Tetralogy of Fallot: Current surgical perspective.2008.","DOI":"10.4103\/0974-2069.43873"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.061143"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12270"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000202"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25471"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq520"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121000366"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.11.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000826"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1574-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2422051994"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2018.08.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2017.0021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2019.0291"},{"key":"e_1_2_9_20_1","unstructured":"CIBC. 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