{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:53:09Z","timestamp":1787064789741,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atherectomy is an important option for debulking atherosclerotic plaque from diseased arteries in patients with infrainguinal arterial disease. Laser atherectomy uses a high\u2010powered laser to remove the plaque from the arteries to restore blood flow.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The Pathfinder multicenter registry was initiated to evaluate the safety and efficacy of the 355\u2009nm laser atherectomy system in a real\u2010world setting for the treatment of de novo, re\u2010stenotic and in\u2010stent restenosis (ISR) lesions in infrainguinal arteries of patients with peripheral artery disease (PAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was a prospective, single\u2010arm, multicenter, open\u2010label registry study for patients treated with the 355\u2009nm laser system. Clinical and lesion characteristics, procedural safety and efficacy data, and baseline, 6\u2010, and 12\u2010month outcomes data, including Ankle Brachial Index (ABI), Rutherford class, and Walking Impairment Questionnaires (WIQ), were collected. The primary efficacy endpoint was the achievement of \u226430% final residual stenosis at the index lesion postatherectomy and adjunctive therapy evaluated by an angiographic Core Lab. The primary safety endpoint was the percentage of subjects who did not experience periprocedural major adverse events (PPMAEs) before discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and two subjects with 121 lesions treated with the 355\u2009nm laser device at 10 centers were included in the analysis. Mean age was 68.4\u2009\u00b1\u200910.21 years, 61.8% of subjects were male, 44.6% had critical limb ischemia (CLI), and 47.3% had tibial lesions. The mean residual stenosis at the end of the procedure was 24.4\u2009\u00b1\u200915.5 with 69 lesions (69.0%) achieving technical procedural success (&lt;30% stenosis); similar rates were observed for subjects with ISR (25.5\u2009\u00b1\u200914.9), chronic total occlusion (CTO) (28.1\u2009\u00b1\u200917.0), and severe calcification (36.5\u2009\u00b1\u200921.6) lesions. Mean ABI, Rutherford, and WIQ scores were improved at both 6 and 12 months. Ninety\u2010seven of 102 subjects (95.1%) met the primary safety endpoint of not experiencing a PPMAE before discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The initial data from the Pathfinder Registry demonstrates the 355\u2009nm laser system is safe and effective in a real\u2010world setting for performing atherectomy in patients with infrainguinal PAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31023","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T02:50:55Z","timestamp":1712112655000},"page":"949-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Solid state, pulsed\u2010wave 355\u2009nm UV laser atherectomy debulking in the treatment of infrainguinal peripheral arterial disease: The Pathfinder Registry"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8456-5978","authenticated-orcid":false,"given":"Tony S.","family":"Das","sequence":"first","affiliation":[{"name":"The Heart Hospital Baylor Plano Plano Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8279-0111","authenticated-orcid":false,"given":"Nicolas W.","family":"Shammas","sequence":"additional","affiliation":[{"name":"Midwest Cardiovascular Research Foundation Davenport Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-800X","authenticated-orcid":false,"given":"Jason A.","family":"Yoho","sequence":"additional","affiliation":[{"name":"The Texas Cardiac and Vascular Institute Corpus Christi Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Martinez\u2010Clark","sequence":"additional","affiliation":[{"name":"Amavita Heart and Vascular Health Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Ramaiah","sequence":"additional","affiliation":[{"name":"Pulse Cardiovascular Institute Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis R.","family":"Leon","sequence":"additional","affiliation":[{"name":"Pima Heart and Vascular Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Pacanowski","sequence":"additional","affiliation":[{"name":"Pima Heart and Vascular Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-1372","authenticated-orcid":false,"given":"Zaheed","family":"Tai","sequence":"additional","affiliation":[{"name":"Comprehensive Cardiovascular Specialists Winter Haven Florida 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