{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:38:09Z","timestamp":1787733489676,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have documented a high rate of implantation success with the ACURATE neo2 valve, as well as a reduction in paravalvular leak (PVL) compared to its predecessor, the ACURATE neo. However, there are no studies that have reviewed and compared the long\u2010term clinical and hemodynamic outcomes of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate the results of the ACURATE neo transcatheter aortic valve in a real\u2010world context, and to compare the results of the outcomes of both generations of this device (ACURATE neo and ACURATE neo2), with a specific focus on procedural success, safety, and long\u2010term effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study including all consecutive patients treated with the ACURATE neo device in seven hospitals was conducted (Clinical Trials Identification Number: NCT03846557). The primary endpoint consisted of a composite of adverse events, including mortality, aortic insufficiency, and other procedural complications. As the second\u2010generation device (ACURATE neo2) replaced the ACURATE neo during the study period, hemodynamic and clinical results before admission, at 30 days, and at 1 year of follow\u2010up were compared between the two generations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 296 patients underwent transcatheter aortic valve implantation with the ACURATE device, with 178 patients receiving the ACURATE neo and 118 patients receiving the ACURATE neo2. In the overall population, the absence of device success occurred in 14.5%. The primary reason for the absence of device success was the presence of para\u2010valvular regurgitation\u2009\u2265\u20092. There were no instances of coronary occlusions, valve embolization, annulus rupture, or procedural deaths. ACURATE neo2 was associated with a significantly higher device success rate (91.7% vs. 82%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), primarily due to a significantly lower rate of para\u2010valvular regurgitation, which remained significant at 1\u2009year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of ACURATE neo and neo2 transcatheter aortic valves is associated with satisfactory clinical results and an extremely low rate of complications. The ACURATE neo2 enables a significantly higher device success rate, primarily attributed to a significant reduction in the rate of PVL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.31032","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T07:03:58Z","timestamp":1712300638000},"page":"1015-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Experience with the ACURATE neo and neo2 transcatheter aortic valves in Spain. The PRECISA (PRospective Evaluation Complementing Investigation with ACURATE devices) registry"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8720-6209","authenticated-orcid":false,"given":"Daniel","family":"T\u00e9bar","sequence":"first","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital Universitario La Paz IdiPAZ Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Hospital German Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Garc\u00eda del Blanco","sequence":"additional","affiliation":[{"name":"Hospital Vall D'Hebron Barcelona Spain"},{"name":"CIBERCV Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Antoni","family":"G\u00f3mez\u2010Hospital","sequence":"additional","affiliation":[{"name":"CIBERCV Madrid Spain"},{"name":"Hospital de Bellvitge Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-8907","authenticated-orcid":false,"given":"Luis","family":"Nombela","sequence":"additional","affiliation":[{"name":"Hospital Clinico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Molina","sequence":"additional","affiliation":[{"name":"Hospital Virgen de las Nievees Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Galeote","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital Universitario La Paz IdiPAZ Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Vilalta","sequence":"additional","affiliation":[{"name":"Hospital German Trias i Pujol Badalona 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